Analysis of weight reduction over time in tirzepatide-treated participants shows early response patterns predict long-term weight loss success.
Key findingAnalysis of weight reduction over time in tirzepatide-treated participants shows early response patt
What the researchers found
Analysis of weight reduction over time in tirzepatide-treated participants shows early response patterns predict long-term weight loss success.
Why it matters
Relevant to peptide therapeutics.
The numbers in context
Early responders: ≥5% weight loss at week 12. Late responders: <5% at week 12. Outcomes measured at weeks 24 and 72.
How the study worked
In publication.
Who was studied
Adults with obesity from the SURMOUNT-1 trial with good treatment adherence
What this study cannot tell us
In publication.
How to read the evidence
Based on design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide evidence.
Questions still open
- Long-term implications?
- Evidence comparison?
- Next steps?
Common questions
What does this mean?
How reliable?
Read the original research
Weight reduction over time in tirzepatide-treated participants by early weight loss response: Post hoc analysis in SURMOUNT-1.
Diabetes, obesity & metabolism, 27(9), 5064-5071
Citation
Ard, Jamy; Lee, Clare J; Gudzune, Kimberly; Addison, Brandi; Lingvay, Ildiko; Cao, Dachuang; Mast, Casey J; Stefanski, Adam; Falcon, Beverly; Mojdami, Donna. (2025). Weight reduction over time in tirzepatide-treated participants by early weight loss response: Post hoc analysis in SURMOUNT-1.. Diabetes, obesity & metabolism, 27(9), 5064-5071. https://doi.org/10.1111/dom.16554