Semaglutide Kidney Benefits Across Different Baseline Function Levels
Analysis of semaglutide effects on kidney function across different baseline levels confirms renal benefits regardless of starting kidney status.
Quick Facts
What This Study Found
Analysis of semaglutide effects on kidney function across different baseline levels confirms renal benefits regardless of starting kidney status.
Key Numbers
Pooled data from SUSTAIN 6 and PIONEER 6. Subgroups analyzed by baseline HbA1c, blood pressure, BMI, and albuminuria status. Outcome: eGFR slope.
How They Did This
In publication.
Why This Research Matters
Relevant to peptide therapeutics.
The Bigger Picture
Advances peptide evidence.
What This Study Doesn't Tell Us
In publication.
Questions This Raises
- ?Long-term implications?
- ?Evidence comparison?
- ?Next steps?
Trust & Context
- Key Stat:
- Key finding Analysis of semaglutide effects on kidney function across different baseline levels confirms renal b
- Evidence Grade:
- Based on design.
- Study Age:
- Published in 2025.
- Original Title:
- Effect of semaglutide on kidney function across different levels of baseline HbA1c, blood pressure, body weight and albuminuria in SUSTAIN 6 and PIONEER 6.
- Published In:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 40(2), 352-359 (2025)
- Authors:
- Apperloo, Ellen M(4), Cherney, David Z I(7), Kuhlman, Anja Birk, Mann, Johannes F E, Rasmussen, Søren, Rossing, Peter, Tuttle, Katherine R, Vrhnjak, Blaz, Heerspink, Hiddo J L
- Database ID:
- RPEP-09959
Evidence Hierarchy
Combines results from multiple studies to find an overall pattern.
What do these levels mean? →Frequently Asked Questions
What does this mean?
Analysis of semaglutide effects on kidney function across different baseline levels confirms renal benefits regardless of starting kidney status.
How reliable?
Consult publication.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-09959APA
Apperloo, Ellen M; Cherney, David Z I; Kuhlman, Anja Birk; Mann, Johannes F E; Rasmussen, Søren; Rossing, Peter; Tuttle, Katherine R; Vrhnjak, Blaz; Heerspink, Hiddo J L. (2025). Effect of semaglutide on kidney function across different levels of baseline HbA1c, blood pressure, body weight and albuminuria in SUSTAIN 6 and PIONEER 6.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 40(2), 352-359. https://doi.org/10.1093/ndt/gfae150
MLA
Apperloo, Ellen M, et al. "Effect of semaglutide on kidney function across different levels of baseline HbA1c, blood pressure, body weight and albuminuria in SUSTAIN 6 and PIONEER 6.." Nephrology, 2025. https://doi.org/10.1093/ndt/gfae150
RethinkPeptides
RethinkPeptides Research Database. "Effect of semaglutide on kidney function across different le..." RPEP-09959. Retrieved from https://rethinkpeptides.com/research/apperloo-2025-effect-of-semaglutide-on
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.