Analysis of semaglutide effects on kidney function across different baseline levels confirms renal benefits regardless of starting kidney status.
Key findingAnalysis of semaglutide effects on kidney function across different baseline levels confirms renal b
What the researchers found
Analysis of semaglutide effects on kidney function across different baseline levels confirms renal benefits regardless of starting kidney status.
Why it matters
Relevant to peptide therapeutics.
The numbers in context
Pooled data from SUSTAIN 6 and PIONEER 6. Subgroups analyzed by baseline HbA1c, blood pressure, BMI, and albuminuria status. Outcome: eGFR slope.
How the study worked
In publication.
Who was studied
Adults with type 2 diabetes and high cardiovascular risk from SUSTAIN 6 and PIONEER 6
What this study cannot tell us
In publication.
How to read the evidence
Based on design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide evidence.
Questions still open
- Long-term implications?
- Evidence comparison?
- Next steps?
Common questions
What does this mean?
How reliable?
Read the original research
Effect of semaglutide on kidney function across different levels of baseline HbA1c, blood pressure, body weight and albuminuria in SUSTAIN 6 and PIONEER 6.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 40(2), 352-359
Citation
Apperloo, Ellen M; Cherney, David Z I; Kuhlman, Anja Birk; Mann, Johannes F E; Rasmussen, Søren; Rossing, Peter; Tuttle, Katherine R; Vrhnjak, Blaz; Heerspink, Hiddo J L. (2025). Effect of semaglutide on kidney function across different levels of baseline HbA1c, blood pressure, body weight and albuminuria in SUSTAIN 6 and PIONEER 6.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 40(2), 352-359. https://doi.org/10.1093/ndt/gfae150