Combined use of high-sensitivity troponin-T and NT-proBNP natriuretic peptide provides superior heart failure diagnostic utility compared to either biomarker alone.
Key findingCombined use of high-sensitivity troponin-T and NT-proBNP natriuretic peptide provides superior hear
What the researchers found
Combined use of high-sensitivity troponin-T and NT-proBNP natriuretic peptide provides superior heart failure diagnostic utility compared to either biomarker alone.
Why it matters
Relevant to peptide therapeutics.
The numbers in context
173 patients underwent TAVI. Elevated BNP is currently the only biomarker in aortic valve guidelines (for asymptomatic severe stenosis).
How the study worked
In publication.
Who was studied
Adults undergoing transcatheter aortic valve implantation (TAVI) for aortic stenosis
What this study cannot tell us
In publication.
How to read the evidence
Based on design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide evidence.
Questions still open
- Long-term implications?
- Evidence comparison?
- Next steps?
Common questions
What does this mean?
How reliable?
Read the original research
Utility of High-Sensitivity Cardiac Troponin-T and N-Terminal Pro-B-Type Natriuretic Peptide to Predict Survival, Quality of Life, and Functional Status Changes After Transcatheter Aortic Valve Implantation.
Journal of the American Heart Association, 14(21), e039898
Citation
Andrews, Tyler; Jabri, Ahmad; McBride, Patrick; Gelovani, David; Beidoun, Mohamad; Giustino, Gennaro; Krafchak, Stephen; Gladney, Stephen; Holmes, Danielle; Wyman, Janet F; Wang, Dee Dee; Eng, Marvin; Aronow, Herb; Lanfear, Dave; O'Neill, William; Engel Gonzalez, Pedro; O'Neill, Brian; Villablanca, Pedro; Lee, James; Jacobsen, Gordon; Cook, Bernard; McCord, James; Frisoli, Tiberio M. (2025). Utility of High-Sensitivity Cardiac Troponin-T and N-Terminal Pro-B-Type Natriuretic Peptide to Predict Survival, Quality of Life, and Functional Status Changes After Transcatheter Aortic Valve Implantation.. Journal of the American Heart Association, 14(21), e039898. https://doi.org/10.1161/JAHA.124.039898