Peptides and Addiction

3 articles in this topic.

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GLP-1 Agonists and Addictive Behavior

Semaglutide and tirzepatide reduce alcohol, nicotine, and cocaine cravings through brain reward circuits. The research evidence from trials to mechanism.

20 min read|Mar 20, 2026

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Peptides and Addiction

Orexin Antagonists and Drug-Seeking Behavior

Orexin receptor antagonists reduce drug-seeking for opioids, cocaine, and alcohol in preclinical models. Review of SORA, DORA evidence and clinical trials.

16 min read|Mar 25, 2026

Peptides and Addiction

Vaccines for Nicotine and Cocaine: Can You Immunize Against Addiction?

Nicotine and cocaine vaccines use hapten-peptide conjugates to generate drug-blocking antibodies. NicVAX failed Phase 3. Fentanyl vaccines are entering trials.

13 min read|Mar 25, 2026