Neuropeptides and Depression

4 articles in this topic.

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Neuropeptides and Depression Beyond Serotonin

Neuropeptides like NPY, CRF, substance P, and oxytocin shape depression biology in ways that SSRIs and serotonin-focused treatments miss entirely.

18 min read|Mar 20, 2026

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Neuropeptides and Depression

Substance P Antagonists for Depression

NK1 receptor antagonists showed antidepressant activity equal to SSRIs in early trials, then failed in phase 3. What went wrong and what the story reveals.

14 min read|Mar 25, 2026

Neuropeptides and Depression

VGF-Derived Peptides: A New Antidepressant Target Class

VGF peptide TLQP-62 matched fluoxetine's antidepressant effects in mice through BDNF, not serotonin. Here's the preclinical evidence.

11 min read|Mar 25, 2026

Neuropeptides and Depression

CRF and Depression: How a Stress Peptide Drives Mood Disorders

Corticotropin-releasing factor (CRF), a 41-amino-acid stress peptide, is elevated in the cerebrospinal fluid of depressed patients and drives HPA axis hyperactivity.

13 min read|Mar 21, 2026