Cell-Penetrating Peptides
Explore peptide research and guides on cell-penetrating peptides.
CPP-Cargo Conjugates: Peptide Delivery of siRNA, Drugs, Genes
CPP-cargo conjugates use cell-penetrating peptides to deliver siRNA, chemotherapy drugs, and gene therapies past cell membranes. The evidence and limits.
Cell-Penetrating PeptidesHow Cell-Penetrating Peptides Escape Endosomes
Most CPPs get trapped in endosomes after entering cells. Here is how pore formation, vesicle budding, and pH-driven mechanisms let peptides reach the cytosol.
Cell-Penetrating PeptidesPenetratin: The Fruit Fly Peptide That Crosses Cells
Penetratin is a 16-amino-acid cell-penetrating peptide from Drosophila Antennapedia that delivers drugs across cell membranes and the blood-brain barrier.
Cell-Penetrating PeptidesTAT Peptide: The HIV-Derived Cancer Delivery Tool
The TAT peptide from HIV-1 can carry anticancer drugs, genes, and nanoparticles into cells that otherwise reject them. Here is what 35 years of research shows.
Cell-Penetrating PeptidesThe TAT Peptide: From HIV Protein to Drug Delivery Tool
How a 9-amino-acid sequence from HIV's TAT protein became the most studied cell-penetrating peptide, with applications from cancer therapy to gene editing.