This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Cyclized and stapled peptides showed improved affinity for Tead cofactors, maintaining selectivity.
Why it matters
These findings could lead to the development of new therapeutic strategies for gastric cancer by targeting specific protein interactions.
How the study worked
The study involved computational design and experimental validation of peptide modifications to enhance binding to Tead-cofactor complexes.
What this study cannot tell us
The study primarily focuses on in vitro findings, which may not fully translate to in vivo conditions.
Read the original research
Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.
Computational biology and chemistry, 94, 107569
Citation
Zhang, Donglei; Wu, Hongna; Zhao, Jing. (2021). Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.. Computational biology and chemistry, 94, 107569. https://doi.org/10.1016/j.compbiolchem.2021.107569