Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.
Quick Facts
What This Study Found
Cyclized and stapled peptides showed improved affinity for Tead cofactors, maintaining selectivity.
Key Numbers
How They Did This
The study involved computational design and experimental validation of peptide modifications to enhance binding to Tead-cofactor complexes.
Why This Research Matters
These findings could lead to the development of new therapeutic strategies for gastric cancer by targeting specific protein interactions.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro findings, which may not fully translate to in vivo conditions.
Trust & Context
- Original Title:
- Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.
- Published In:
- Computational biology and chemistry, 94, 107569 (2021)
- Authors:
- Zhang, Donglei, Wu, Hongna, Zhao, Jing
- Database ID:
- RPEP-05925
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05925APA
Zhang, Donglei; Wu, Hongna; Zhao, Jing. (2021). Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.. Computational biology and chemistry, 94, 107569. https://doi.org/10.1016/j.compbiolchem.2021.107569
MLA
Zhang, Donglei, et al. "Computational design and experimental substantiation of conformationally constrained peptides from the complex interfaces of transcriptional enhanced associate domains with their cofactors in gastric cancer.." Computational biology and chemistry, 2021. https://doi.org/10.1016/j.compbiolchem.2021.107569
RethinkPeptides
RethinkPeptides Research Database. "Computational design and experimental substantiation of conf..." RPEP-05925. Retrieved from https://rethinkpeptides.com/research/zhang-2021-computational-design-and-experimental
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.