How a Disulfide Bond Controls Insulin-Like Peptide 3 Receptor Binding and Activation
The intra-A-chain disulfide bond of INSL3 was essential for RXFP2 receptor binding and activation, revealing structural requirements for this reproductive peptide's function in fertility and testicular descent.
Quick Facts
What This Study Found
The intra-A-chain disulfide bond of INSL3 was essential for RXFP2 receptor binding and activation, revealing structural requirements for this reproductive peptide's function in fertility and testicular descent.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding The intra-A-chain disulfide bond of INSL3 was essential for RXFP2 receptor binding and activation, revealing structural requirements for this reproduc
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2010.
- Original Title:
- Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2.
- Published In:
- Peptides, 31(9), 1730-6 (2010)
- Authors:
- Zhang, Suode, Hughes, Richard A, Bathgate, Ross A D(3), Shabanpoor, Fazel, Hossain, M Akhter, Lin, Feng, van Lierop, Bianca, Robinson, Andrea J, Wade, John D
- Database ID:
- RPEP-01715
Evidence Hierarchy
Frequently Asked Questions
What was studied?
How a Disulfide Bond Controls Insulin-Like Peptide 3 Receptor Binding and Activation
What was found?
The intra-A-chain disulfide bond of INSL3 was essential for RXFP2 receptor binding and activation, revealing structural requirements for this reproductive peptide's function in fertility and testicular descent.
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-01715APA
Zhang, Suode; Hughes, Richard A; Bathgate, Ross A D; Shabanpoor, Fazel; Hossain, M Akhter; Lin, Feng; van Lierop, Bianca; Robinson, Andrea J; Wade, John D. (2010). Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2.. Peptides, 31(9), 1730-6. https://doi.org/10.1016/j.peptides.2010.05.021
MLA
Zhang, Suode, et al. "Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2.." Peptides, 2010. https://doi.org/10.1016/j.peptides.2010.05.021
RethinkPeptides
RethinkPeptides Research Database. "Role of the intra-A-chain disulfide bond of insulin-like pep..." RPEP-01715. Retrieved from https://rethinkpeptides.com/research/zhang-2010-role-of-the-intraachain
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.