This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Men with the C-allele of m.1382A>C showed a higher prevalence of T2D, particularly in low physical activity groups.
Why it matters
Understanding the genetic factors that contribute to T2D can help in developing targeted prevention strategies, especially in high-risk populations. This research highlights the importance of considering genetic variations in the context of lifestyle factors like physical activity.
How the study worked
The study involved a meta-analysis of three cohorts totaling 27,527 participants, alongside animal experiments using high-fat fed male mice.
What this study cannot tell us
The study primarily focuses on male participants, limiting the applicability of findings to females. Additionally, results from animal models may not fully translate to human conditions.
Read the original research
A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
Aging, 13(2), 1692-1717
Citation
Zempo, Hirofumi; Kim, Su-Jeong; Fuku, Noriyuki; Nishida, Yuichiro; Higaki, Yasuki; Wan, Junxiang; Yen, Kelvin; Miller, Brendan; Vicinanza, Roberto; Miyamoto-Mikami, Eri; Kumagai, Hiroshi; Naito, Hisashi; Xiao, Jialin; Mehta, Hemal H; Lee, Changhan; Hara, Megumi; Patel, Yesha M; Setiawan, Veronica W; Moore, Timothy M; Hevener, Andrea L; Sutoh, Yoichi; Shimizu, Atsushi; Kojima, Kaname; Kinoshita, Kengo; Arai, Yasumichi; Hirose, Nobuyoshi; Maeda, Seiji; Tanaka, Keitaro; Cohen, Pinchas. (2021). A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.. Aging, 13(2), 1692-1717. https://doi.org/10.18632/aging.202529