A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
Quick Facts
What This Study Found
Men with the C-allele of m.1382A>C showed a higher prevalence of T2D, particularly in low physical activity groups.
Key Numbers
How They Did This
The study involved a meta-analysis of three cohorts totaling 27,527 participants, alongside animal experiments using high-fat fed male mice.
Why This Research Matters
Understanding the genetic factors that contribute to T2D can help in developing targeted prevention strategies, especially in high-risk populations. This research highlights the importance of considering genetic variations in the context of lifestyle factors like physical activity.
What This Study Doesn't Tell Us
The study primarily focuses on male participants, limiting the applicability of findings to females. Additionally, results from animal models may not fully translate to human conditions.
Trust & Context
- Original Title:
- A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
- Published In:
- Aging, 13(2), 1692-1717 (2021)
- Authors:
- Zempo, Hirofumi, Kim, Su-Jeong(3), Fuku, Noriyuki, Nishida, Yuichiro, Higaki, Yasuki, Wan, Junxiang, Yen, Kelvin, Miller, Brendan, Vicinanza, Roberto, Miyamoto-Mikami, Eri, Kumagai, Hiroshi, Naito, Hisashi, Xiao, Jialin, Mehta, Hemal H, Lee, Changhan, Hara, Megumi, Patel, Yesha M, Setiawan, Veronica W, Moore, Timothy M, Hevener, Andrea L, Sutoh, Yoichi, Shimizu, Atsushi, Kojima, Kaname, Kinoshita, Kengo, Arai, Yasumichi, Hirose, Nobuyoshi, Maeda, Seiji, Tanaka, Keitaro, Cohen, Pinchas
- Database ID:
- RPEP-05924
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05924APA
Zempo, Hirofumi; Kim, Su-Jeong; Fuku, Noriyuki; Nishida, Yuichiro; Higaki, Yasuki; Wan, Junxiang; Yen, Kelvin; Miller, Brendan; Vicinanza, Roberto; Miyamoto-Mikami, Eri; Kumagai, Hiroshi; Naito, Hisashi; Xiao, Jialin; Mehta, Hemal H; Lee, Changhan; Hara, Megumi; Patel, Yesha M; Setiawan, Veronica W; Moore, Timothy M; Hevener, Andrea L; Sutoh, Yoichi; Shimizu, Atsushi; Kojima, Kaname; Kinoshita, Kengo; Arai, Yasumichi; Hirose, Nobuyoshi; Maeda, Seiji; Tanaka, Keitaro; Cohen, Pinchas. (2021). A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.. Aging, 13(2), 1692-1717. https://doi.org/10.18632/aging.202529
MLA
Zempo, Hirofumi, et al. "A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.." Aging, 2021. https://doi.org/10.18632/aging.202529
RethinkPeptides
RethinkPeptides Research Database. "A pro-diabetogenic mtDNA polymorphism in the mitochondrial-d..." RPEP-05924. Retrieved from https://rethinkpeptides.com/research/zempo-2021-a-prodiabetogenic-mtdna-polymorphism
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.