Hyperbaric oxygen produced prolonged pain relief through a NO-dependent, opioid-mediated mechanism — both nitric oxide signaling and endogenous opioid peptide release were required for the analgesic effect.
Key findingHyperbaric oxygen produced prolonged pain relief through a NO-dependent, opioid-mediated mechanism — both nitric oxide signaling and endogenous opioid
What the researchers found
Hyperbaric oxygen produced prolonged pain relief through a NO-dependent, opioid-mediated mechanism — both nitric oxide signaling and endogenous opioid peptide release were required for the analgesic effect.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
The journal of pain, 10(2), 167-72
Citation
Zelinski, Lisa M; Ohgami, Yusuke; Chung, Eunhee; Shirachi, Donald Y; Quock, Raymond M. (2009). A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.. The journal of pain, 10(2), 167-72. https://doi.org/10.1016/j.jpain.2008.08.003