Opioid Peptides Control Cancer Cell Differentiation: Met-Enkephalin Makes Cancer Cells Mature
The opioid growth factor (met-enkephalin/OGF) promoted differentiation of human cancer cells, pushing them from immature proliferative states toward mature, less aggressive phenotypes through the OGFr pathway.
Quick Facts
What This Study Found
Met-enkephalin (OGF) through the OGFr receptor promoted differentiation of human cancer cells toward more mature phenotypes, reducing proliferative capacity — adding differentiation induction to its known growth-inhibitory anti-cancer mechanism.
Key Numbers
How They Did This
in-vitro study on opioid-peptides, cancer.
Why This Research Matters
Relevant for opioid-peptides, cancer.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Met-enkephalin (OGF) through the OGFr receptor promoted differentiation of human cancer cells toward more mature phenotypes, reducing proliferative ca
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Opioids and differentiation in human cancer cells.
- Published In:
- Neuropeptides, 39(5), 495-505 (2005)
- Authors:
- Zagon, Ian S(3), McLaughlin, Patricia J(3)
- Database ID:
- RPEP-01106
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Opioid Peptides Control Cancer Cell Differentiation: Met-Enkephalin Makes Cancer Cells Mature
What was found?
The opioid growth factor (met-enkephalin/OGF) promoted differentiation of human cancer cells, pushing them from immature proliferative states toward mature, less aggressive phenotypes through the OGFr pathway.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01106APA
Zagon, Ian S; McLaughlin, Patricia J. (2005). Opioids and differentiation in human cancer cells.. Neuropeptides, 39(5), 495-505.
MLA
Zagon, Ian S, et al. "Opioids and differentiation in human cancer cells.." Neuropeptides, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Opioids and differentiation in human cancer cells." RPEP-01106. Retrieved from https://rethinkpeptides.com/research/zagon-2005-opioids-and-differentiation-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.