Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Quick Facts
What This Study Found
The peptide achieves single-digit nanomolar inhibition of SARS-CoV-2.
Key Numbers
How They Did This
The study involved structural analysis of the spike protein and testing the peptide's effectiveness in cell-based and virus-based assays.
Why This Research Matters
This research is significant as it addresses the urgent need for effective antiviral treatments against evolving SARS-CoV-2 variants. The findings may lead to new therapeutic options that are less susceptible to mutations.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro results, which may not fully translate to clinical effectiveness in humans.
Trust & Context
- Original Title:
- Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 119(40), e2210990119 (2022)
- Authors:
- Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J B, Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J, White, K Ian, Held, Richard G, Subramanian, Subu, Marcus, Kendra, Pfuetzner, Richard A, Esquivies, Luis, Doyle, Catherine A, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tom, Brunger, Axel T
- Database ID:
- RPEP-06624
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06624APA
Yang, Kailu; Wang, Chuchu; Kreutzberger, Alex J B; Ojha, Ravi; Kuivanen, Suvi; Couoh-Cardel, Sergio; Muratcioglu, Serena; Eisen, Timothy J; White, K Ian; Held, Richard G; Subramanian, Subu; Marcus, Kendra; Pfuetzner, Richard A; Esquivies, Luis; Doyle, Catherine A; Kuriyan, John; Vapalahti, Olli; Balistreri, Giuseppe; Kirchhausen, Tom; Brunger, Axel T. (2022). Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.. Proceedings of the National Academy of Sciences of the United States of America, 119(40), e2210990119. https://doi.org/10.1073/pnas.2210990119
MLA
Yang, Kailu, et al. "Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.." Proceedings of the National Academy of Sciences of the United States of America, 2022. https://doi.org/10.1073/pnas.2210990119
RethinkPeptides
RethinkPeptides Research Database. "Nanomolar inhibition of SARS-CoV-2 infection by an unmodifie..." RPEP-06624. Retrieved from https://rethinkpeptides.com/research/yang-2022-nanomolar-inhibition-of-sarscov2
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.