Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant.
Quick Facts
What This Study Found
Heat-iMVA improved T cell and antibody responses, extending survival and delaying tumor growth.
Key Numbers
How They Did This
The study employed a therapeutic vaccination model using tumor neoantigen peptide vaccines and SARS-CoV-2 spike protein to assess the adjuvant effects of heat-iMVA.
Why This Research Matters
Enhancing immune responses in vaccines is crucial for effective cancer and COVID-19 treatments. Heat-iMVA could lead to more effective vaccines.
What This Study Doesn't Tell Us
The study primarily focuses on preclinical models, and results may not directly translate to human applications.
Trust & Context
- Original Title:
- Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant.
- Published In:
- NPJ vaccines, 7(1), 120 (2022)
- Authors:
- Yang, Ning, Garcia, Aitor, Meyer, Cindy, Tuschl, Thomas, Merghoub, Taha, Wolchok, Jedd D, Deng, Liang
- Database ID:
- RPEP-06627
Evidence Hierarchy
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-06627APA
Yang, Ning; Garcia, Aitor; Meyer, Cindy; Tuschl, Thomas; Merghoub, Taha; Wolchok, Jedd D; Deng, Liang. (2022). Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant.. NPJ vaccines, 7(1), 120. https://doi.org/10.1038/s41541-022-00542-5
MLA
Yang, Ning, et al. "Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant.." NPJ vaccines, 2022. https://doi.org/10.1038/s41541-022-00542-5
RethinkPeptides
RethinkPeptides Research Database. "Heat-inactivated modified vaccinia virus Ankara boosts Th1 c..." RPEP-06627. Retrieved from https://rethinkpeptides.com/research/yang-2022-heatinactivated-modified-vaccinia-virus
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.