Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.
Quick Facts
What This Study Found
The AFG/fSAP hydrogel bridged a 15-mm sciatic nerve gap in rats and improved functional recovery.
Key Numbers
How They Did This
The study involved creating a hydrogel through electrospinning and molecular self-assembly, followed by in vitro and in vivo testing in rats.
Why This Research Matters
This research offers a new approach to nerve repair that could enhance recovery outcomes for patients with peripheral nerve injuries. It may provide an alternative to traditional nerve grafts, which have limitations.
What This Study Doesn't Tell Us
The study was conducted in rats, and results may not directly translate to humans. Long-term effects and safety in humans remain to be evaluated.
Trust & Context
- Original Title:
- Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.
- Published In:
- Bioactive materials, 8, 529-544 (2022)
- Authors:
- Yang, Shuhui, Zhu, Jinjin, Lu, Changfeng, Chai, Yi, Cao, Zheng, Lu, Jiaju, Zhang, Zhe, Zhao, He, Huang, Yin-Yuan, Yao, Shenglian, Kong, Xiangdong, Zhang, Peixun, Wang, Xiumei
- Database ID:
- RPEP-06629
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06629APA
Yang, Shuhui; Zhu, Jinjin; Lu, Changfeng; Chai, Yi; Cao, Zheng; Lu, Jiaju; Zhang, Zhe; Zhao, He; Huang, Yin-Yuan; Yao, Shenglian; Kong, Xiangdong; Zhang, Peixun; Wang, Xiumei. (2022). Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.. Bioactive materials, 8, 529-544. https://doi.org/10.1016/j.bioactmat.2021.05.056
MLA
Yang, Shuhui, et al. "Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.." Bioactive materials, 2022. https://doi.org/10.1016/j.bioactmat.2021.05.056
RethinkPeptides
RethinkPeptides Research Database. "Aligned fibrin/functionalized self-assembling peptide interp..." RPEP-06629. Retrieved from https://rethinkpeptides.com/research/yang-2022-aligned-fibrinfunctionalized-selfassembling-peptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.