AVP enhanced synthesis and secretion of met-enkephalin and beta-endorphin in the periaqueductal gray (PAG) — the brain's primary pain control center — revealing a vasopressin-opioid interaction for pain modulation.
Key findingArginine vasopressin stimulated enkephalin and endorphin synthesis and secretion in the periaqueductal gray, demonstrating vasopressin-opioid peptide
What the researchers found
Arginine vasopressin stimulated enkephalin and endorphin synthesis and secretion in the periaqueductal gray, demonstrating vasopressin-opioid peptide cross-talk in the brain's primary descending pain modulation center.
Why it matters
Relevant for opioid-peptides, neuropeptides, pain.
How the study worked
in-vitro study on opioid-peptides, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Arginine vasopressin enhances periaqueductal gray synthesis and secretion of enkephalin and endorphin in the rat.
Brain research bulletin, 71(1-3), 193-9
Citation
Yang, Jun; Yang, Yu; Xu, Hong-Tao; Chen, Jian-Min; Liu, Wen-Yan; Lin, Bao-Chen. (2006). Arginine vasopressin enhances periaqueductal gray synthesis and secretion of enkephalin and endorphin in the rat.. Brain research bulletin, 71(1-3), 193-9.