This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
The modified exosomes increased cellular delivery of G3139 and downregulated Bcl-2.
Why it matters
This research offers a simpler method for delivering nucleic acids, which could enhance the effectiveness of cancer therapies. It also opens up new avenues for personalized medicine.
How the study worked
The study involved engineering exosomes with cell-penetrating peptides and testing their ability to deliver antisense oligonucleotides in vitro.
What this study cannot tell us
The study was conducted in vitro, and results may not directly translate to human patients.
Read the original research
A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.
ACS applied materials & interfaces, 13(9), 10760-10767
Citation
Xu, Huiying; Liao, Chong; Liang, Shifu; Ye, Bang-Ce. (2021). A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.. ACS applied materials & interfaces, 13(9), 10760-10767. https://doi.org/10.1021/acsami.1c00016