A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.
Quick Facts
What This Study Found
The modified exosomes increased cellular delivery of G3139 and downregulated Bcl-2.
Key Numbers
How They Did This
The study involved engineering exosomes with cell-penetrating peptides and testing their ability to deliver antisense oligonucleotides in vitro.
Why This Research Matters
This research offers a simpler method for delivering nucleic acids, which could enhance the effectiveness of cancer therapies. It also opens up new avenues for personalized medicine.
What This Study Doesn't Tell Us
The study was conducted in vitro, and results may not directly translate to human patients.
Trust & Context
- Original Title:
- A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.
- Published In:
- ACS applied materials & interfaces, 13(9), 10760-10767 (2021)
- Authors:
- Xu, Huiying, Liao, Chong, Liang, Shifu, Ye, Bang-Ce
- Database ID:
- RPEP-05891
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05891APA
Xu, Huiying; Liao, Chong; Liang, Shifu; Ye, Bang-Ce. (2021). A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.. ACS applied materials & interfaces, 13(9), 10760-10767. https://doi.org/10.1021/acsami.1c00016
MLA
Xu, Huiying, et al. "A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides.." ACS applied materials & interfaces, 2021. https://doi.org/10.1021/acsami.1c00016
RethinkPeptides
RethinkPeptides Research Database. "A Novel Peptide-Equipped Exosomes Platform for Delivery of A..." RPEP-05891. Retrieved from https://rethinkpeptides.com/research/xu-2021-a-novel-peptideequipped-exosomes
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.