This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Ablation of Tet3 in AGRP neurons caused hyperphagia, obesity, and diabetes in mice.
Why it matters
Understanding how TET3 regulates appetite and stress can inform treatments for obesity and related metabolic disorders. This research highlights the complex interplay between feeding behaviors and stress responses.
How the study worked
The study utilized CRISPR technology to genetically remove TET3 from AGRP neurons in adult mice and assessed the resulting behavioral and metabolic changes.
What this study cannot tell us
The study was conducted in mice, so results may not directly apply to humans. Further research is needed to explore TET3's role in human physiology.
Read the original research
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
The Journal of clinical investigation, 132(19)
Citation
Xie, Di; Stutz, Bernardo; Li, Feng; Chen, Fan; Lv, Haining; Sestan-Pesa, Matija; Catarino, Jonatas; Gu, Jianlei; Zhao, Hongyu; Stoddard, Christopher E; Carmichael, Gordon G; Shanabrough, Marya; Taylor, Hugh S; Liu, Zhong-Wu; Gao, Xiao-Bing; Horvath, Tamas L; Huang, Yingqun. (2022). TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.. The Journal of clinical investigation, 132(19). https://doi.org/10.1172/JCI162365