TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
Quick Facts
What This Study Found
Ablation of Tet3 in AGRP neurons caused hyperphagia, obesity, and diabetes in mice.
Key Numbers
How They Did This
The study utilized CRISPR technology to genetically remove TET3 from AGRP neurons in adult mice and assessed the resulting behavioral and metabolic changes.
Why This Research Matters
Understanding how TET3 regulates appetite and stress can inform treatments for obesity and related metabolic disorders. This research highlights the complex interplay between feeding behaviors and stress responses.
What This Study Doesn't Tell Us
The study was conducted in mice, so results may not directly apply to humans. Further research is needed to explore TET3's role in human physiology.
Trust & Context
- Original Title:
- TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
- Published In:
- The Journal of clinical investigation, 132(19) (2022)
- Authors:
- Xie, Di, Stutz, Bernardo, Li, Feng, Chen, Fan, Lv, Haining, Sestan-Pesa, Matija, Catarino, Jonatas, Gu, Jianlei, Zhao, Hongyu, Stoddard, Christopher E, Carmichael, Gordon G, Shanabrough, Marya, Taylor, Hugh S, Liu, Zhong-Wu, Gao, Xiao-Bing, Horvath, Tamas L, Huang, Yingqun
- Database ID:
- RPEP-06606
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06606APA
Xie, Di; Stutz, Bernardo; Li, Feng; Chen, Fan; Lv, Haining; Sestan-Pesa, Matija; Catarino, Jonatas; Gu, Jianlei; Zhao, Hongyu; Stoddard, Christopher E; Carmichael, Gordon G; Shanabrough, Marya; Taylor, Hugh S; Liu, Zhong-Wu; Gao, Xiao-Bing; Horvath, Tamas L; Huang, Yingqun. (2022). TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.. The Journal of clinical investigation, 132(19). https://doi.org/10.1172/JCI162365
MLA
Xie, Di, et al. "TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.." The Journal of clinical investigation, 2022. https://doi.org/10.1172/JCI162365
RethinkPeptides
RethinkPeptides Research Database. "TET3 epigenetically controls feeding and stress response beh..." RPEP-06606. Retrieved from https://rethinkpeptides.com/research/xie-2022-tet3-epigenetically-controls-feeding
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.