Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
Quick Facts
What This Study Found
Stapled Ano-3/3s peptides showed superior tumor cell-selective cytotoxicity and induced tumor ablation in mice.
Key Numbers
How They Did This
The study involved synthesizing stapled anoplin peptides and testing their effects on melanoma and triple-negative breast cancer in mouse models.
Why This Research Matters
This research highlights a novel approach to enhance the effectiveness of oncolytic therapies, potentially leading to better cancer treatments. It also emphasizes the role of the immune system in combating tumors.
What This Study Doesn't Tell Us
The study was conducted in mouse models, and results may not directly translate to human patients.
Trust & Context
- Original Title:
- Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
- Published In:
- Journal of medicinal chemistry, 64(9), 5802-5815 (2021)
- Authors:
- Wu, Ye, Lu, Dong, Jiang, Yixin, Jin, Jinmei, Liu, Sanhong, Chen, Lili, Zhang, Hong, Zhou, Yudong, Chen, Hongzhuan, Nagle, Dale G, Luan, Xin, Zhang, Weidong
- Database ID:
- RPEP-05881
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05881APA
Wu, Ye; Lu, Dong; Jiang, Yixin; Jin, Jinmei; Liu, Sanhong; Chen, Lili; Zhang, Hong; Zhou, Yudong; Chen, Hongzhuan; Nagle, Dale G; Luan, Xin; Zhang, Weidong. (2021). Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.. Journal of medicinal chemistry, 64(9), 5802-5815. https://doi.org/10.1021/acs.jmedchem.0c02237
MLA
Wu, Ye, et al. "Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.." Journal of medicinal chemistry, 2021. https://doi.org/10.1021/acs.jmedchem.0c02237
RethinkPeptides
RethinkPeptides Research Database. "Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chai..." RPEP-05881. Retrieved from https://rethinkpeptides.com/research/wu-2021-stapled-wasp-venomderived-oncolytic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.