Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.
Quick Facts
What This Study Found
TAT-Lip significantly reduced drug loss rate and enhanced anti-inflammatory effects.
Key Numbers
How They Did This
The study used in vitro assays and in vivo pharmacokinetics assessments in rabbits to evaluate the effectiveness of TAT-functionalized liposomes.
Why This Research Matters
Improving drug delivery to the eye can enhance treatment outcomes for various ocular diseases. This research could lead to better therapies with fewer side effects.
What This Study Doesn't Tell Us
The study primarily used animal models, which may not fully predict human responses.
Trust & Context
- Original Title:
- Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.
- Published In:
- International journal of pharmaceutics, 598, 120405 (2021)
- Authors:
- Wu, Baohuan, Li, Mengshun, Li, Keke, Hong, Wei, Lv, Qingzhi, Li, Youjie, Xie, Shuyang, Han, Jingtian, Tian, Baocheng
- Database ID:
- RPEP-05878
Evidence Hierarchy
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-05878APA
Wu, Baohuan; Li, Mengshun; Li, Keke; Hong, Wei; Lv, Qingzhi; Li, Youjie; Xie, Shuyang; Han, Jingtian; Tian, Baocheng. (2021). Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.. International journal of pharmaceutics, 598, 120405. https://doi.org/10.1016/j.ijpharm.2021.120405
MLA
Wu, Baohuan, et al. "Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.." International journal of pharmaceutics, 2021. https://doi.org/10.1016/j.ijpharm.2021.120405
RethinkPeptides
RethinkPeptides Research Database. "Cell penetrating peptide TAT-functionalized liposomes for ef..." RPEP-05878. Retrieved from https://rethinkpeptides.com/research/wu-2021-cell-penetrating-peptide-tatfunctionalized
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.