This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
TAT-Lip significantly reduced drug loss rate and enhanced anti-inflammatory effects.
Why it matters
Improving drug delivery to the eye can enhance treatment outcomes for various ocular diseases. This research could lead to better therapies with fewer side effects.
How the study worked
The study used in vitro assays and in vivo pharmacokinetics assessments in rabbits to evaluate the effectiveness of TAT-functionalized liposomes.
What this study cannot tell us
The study primarily used animal models, which may not fully predict human responses.
Read the original research
Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.
International journal of pharmaceutics, 598, 120405
Citation
Wu, Baohuan; Li, Mengshun; Li, Keke; Hong, Wei; Lv, Qingzhi; Li, Youjie; Xie, Shuyang; Han, Jingtian; Tian, Baocheng. (2021). Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility.. International journal of pharmaceutics, 598, 120405. https://doi.org/10.1016/j.ijpharm.2021.120405