Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.
Quick Facts
What This Study Found
In Xhosa females, the NPY rs5573 A allele increased anxiety sensitivity (p=0.035), while the rs3037354 deletion variant decreased it (p=0.034).
Key Numbers
How They Did This
The study used a cross-sectional design to analyze genetic variants and their interaction with childhood trauma in a sample of 951 adolescents.
Why This Research Matters
Understanding how genetic and environmental factors interact can help identify individuals at risk for anxiety disorders. This research emphasizes the importance of considering diverse populations in psychiatric genetics.
What This Study Doesn't Tell Us
The study's cross-sectional design limits causal inferences, and the findings may not generalize beyond the specific ethnic groups studied.
Trust & Context
- Original Title:
- Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.
- Published In:
- Anxiety, stress, and coping, 34(4), 450-464 (2021)
- Authors:
- Womersley, Jacqueline Samantha, Martin, Lindi, van der Merwe, Lize, Seedat, Soraya, Hemmings, Sian Megan Joanna
- Database ID:
- RPEP-05875
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05875APA
Womersley, Jacqueline Samantha; Martin, Lindi; van der Merwe, Lize; Seedat, Soraya; Hemmings, Sian Megan Joanna. (2021). Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.. Anxiety, stress, and coping, 34(4), 450-464. https://doi.org/10.1080/10615806.2021.1876225
MLA
Womersley, Jacqueline Samantha, et al. "Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.." Anxiety, 2021. https://doi.org/10.1080/10615806.2021.1876225
RethinkPeptides
RethinkPeptides Research Database. "Genetic variation in neuropeptide Y interacts with childhood..." RPEP-05875. Retrieved from https://rethinkpeptides.com/research/womersley-2021-genetic-variation-in-neuropeptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.