This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
In Xhosa females, the NPY rs5573 A allele increased anxiety sensitivity (p=0.035), while the rs3037354 deletion variant decreased it (p=0.034).
Why it matters
Understanding how genetic and environmental factors interact can help identify individuals at risk for anxiety disorders. This research emphasizes the importance of considering diverse populations in psychiatric genetics.
How the study worked
The study used a cross-sectional design to analyze genetic variants and their interaction with childhood trauma in a sample of 951 adolescents.
What this study cannot tell us
The study's cross-sectional design limits causal inferences, and the findings may not generalize beyond the specific ethnic groups studied.
Read the original research
Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.
Anxiety, stress, and coping, 34(4), 450-464
Citation
Womersley, Jacqueline Samantha; Martin, Lindi; van der Merwe, Lize; Seedat, Soraya; Hemmings, Sian Megan Joanna. (2021). Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.. Anxiety, stress, and coping, 34(4), 450-464. https://doi.org/10.1080/10615806.2021.1876225