Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.
Quick Facts
What This Study Found
Elamipretide treatment for 8 weeks almost completely reversed age-related increases in S-glutathionylation in mouse hearts.
Key Numbers
How They Did This
The study used shotgun proteomics to analyze the S-glutathionylation and phosphorylation of heart proteins in young and old mice, comparing the effects of elamipretide treatment.
Why This Research Matters
Understanding how elamipretide reverses age-related changes in heart proteins could lead to new therapies for age-associated heart diseases. This research highlights potential interventions to improve heart health in older adults.
What This Study Doesn't Tell Us
The study was conducted in mice, so results may not directly translate to humans. Further research is needed to explore long-term effects and safety in humans.
Trust & Context
- Original Title:
- Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.
- Published In:
- GeroScience, 43(5), 2395-2412 (2021)
- Authors:
- Whitson, Jeremy A, Martín-Pérez, Miguel, Zhang, Tong(2), Gaffrey, Matthew J, Merrihew, Gennifer E, Huang, Eric, White, Collin C, Kavanagh, Terrance J, Qian, Wei-Jun, Campbell, Matthew D, MacCoss, Michael J, Marcinek, David J, Villén, Judit, Rabinovitch, Peter S
- Database ID:
- RPEP-05871
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05871APA
Whitson, Jeremy A; Martín-Pérez, Miguel; Zhang, Tong; Gaffrey, Matthew J; Merrihew, Gennifer E; Huang, Eric; White, Collin C; Kavanagh, Terrance J; Qian, Wei-Jun; Campbell, Matthew D; MacCoss, Michael J; Marcinek, David J; Villén, Judit; Rabinovitch, Peter S. (2021). Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.. GeroScience, 43(5), 2395-2412. https://doi.org/10.1007/s11357-021-00447-6
MLA
Whitson, Jeremy A, et al. "Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.." GeroScience, 2021. https://doi.org/10.1007/s11357-021-00447-6
RethinkPeptides
RethinkPeptides Research Database. "Elamipretide (SS-31) treatment attenuates age-associated pos..." RPEP-05871. Retrieved from https://rethinkpeptides.com/research/whitson-2021-elamipretide-ss31-treatment-attenuates
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.