Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.

Wharton, Sean et al.·The New England journal of medicine·2025·
RPEP-141422025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Not classified
Evidence
Not graded
Sample
Not reported

What This Study Found

Key Numbers

How They Did This

Why This Research Matters

What This Study Doesn't Tell Us

Trust & Context

Original Title:
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.
Published In:
The New England journal of medicine, 393(18), 1796-1806 (2025)
Database ID:
RPEP-14142

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
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Cite This Study

RPEP-14142·https://rethinkpeptides.com/research/RPEP-14142

APA

Wharton, Sean; Aronne, Louis J; Stefanski, Adam; Alfaris, Nasreen F; Ciudin, Andreea; Yokote, Koutaro; Halpern, Bruno; Shukla, Alpana P; Zhou, Chunmei; Macpherson, Lisa; Allen, Sheryl E; Ahmad, Nadia N; Klise, Suzanne R. (2025). Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.. The New England journal of medicine, 393(18), 1796-1806. https://doi.org/10.1056/NEJMoa2511774

MLA

Wharton, Sean, et al. "Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.." The New England journal of medicine, 2025. https://doi.org/10.1056/NEJMoa2511774

RethinkPeptides

RethinkPeptides Research Database. "Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist ..." RPEP-14142. Retrieved from https://rethinkpeptides.com/research/wharton-2025-orforglipron-an-oral-smallmolecule

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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.