Substance P and the regulation of inflammation in infections and inflammatory bowel disease.
Quick Facts
What This Study Found
Substance P and hemokinin-1, produced by lymphocytes and macrophages, act through the neurokinin-1 receptor to enhance proinflammatory cytokine production, amplifying inflammation in infections and inflammatory bowel disease. Their synthesis and receptor expression are regulated by cytokines such as IL12, IL23, IL18, TNFα, IL10, and TGFβ, indicating a complex immune regulatory circuit.
Key Numbers
How They Did This
This study reviews existing research on the production and regulation of Substance P and hemokinin-1 by immune cells, their receptor interactions, and their role in inflammation during infections and inflammatory bowel disease, including evidence from animal models.
Why This Research Matters
Understanding how Substance P regulates inflammation can help develop new treatments targeting immune responses in infections and inflammatory bowel diseases, potentially improving patient outcomes.
What This Study Doesn't Tell Us
The study is a review and does not provide new experimental data; some cytokines regulating hemokinin-1 production remain unidentified, and the exact mechanisms in humans need further research.
Trust & Context
- Original Title:
- Substance P and the regulation of inflammation in infections and inflammatory bowel disease.
- Published In:
- Acta physiologica (Oxford, England), 213(2), 453-61 (2015)
- Authors:
- Weinstock, J V
- Database ID:
- RPEP-02834
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02834APA
Weinstock, J V. (2015). Substance P and the regulation of inflammation in infections and inflammatory bowel disease.. Acta physiologica (Oxford, England), 213(2), 453-61. https://doi.org/10.1111/apha.12428
MLA
Weinstock, J V. "Substance P and the regulation of inflammation in infections and inflammatory bowel disease.." Acta physiologica (Oxford, 2015. https://doi.org/10.1111/apha.12428
RethinkPeptides
RethinkPeptides Research Database. "Substance P and the regulation of inflammation in infections..." RPEP-02834. Retrieved from https://rethinkpeptides.com/research/weinstock-2015-substance-p-and-the
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.