This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Substance P and hemokinin-1, produced by lymphocytes and macrophages, act through the neurokinin-1 receptor to enhance proinflammatory cytokine production, amplifying inflammation in infections and inflammatory bowel disease. Their synthesis and receptor expression are regulated by cytokines such as IL12, IL23, IL18, TNFα, IL10, and TGFβ, indicating a complex immune regulatory circuit.
Why it matters
Understanding how Substance P regulates inflammation can help develop new treatments targeting immune responses in infections and inflammatory bowel diseases, potentially improving patient outcomes.
How the study worked
This study reviews existing research on the production and regulation of Substance P and hemokinin-1 by immune cells, their receptor interactions, and their role in inflammation during infections and inflammatory bowel disease, including evidence from animal models.
What this study cannot tell us
The study is a review and does not provide new experimental data; some cytokines regulating hemokinin-1 production remain unidentified, and the exact mechanisms in humans need further research.
Read the original research
Substance P and the regulation of inflammation in infections and inflammatory bowel disease.
Acta physiologica (Oxford, England), 213(2), 453-61
Citation
Weinstock, J V. (2015). Substance P and the regulation of inflammation in infections and inflammatory bowel disease.. Acta physiologica (Oxford, England), 213(2), 453-61. https://doi.org/10.1111/apha.12428