This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
The review identifies key factors influencing the passive permeability and oral bioavailability of cyclic peptides, emphasizing structural features that enhance absorption. It highlights that cyclic peptides, unlike linear ones, can achieve drug-like oral bioavailability, as demonstrated by compounds such as cyclosporine A.
Why it matters
Understanding what makes cyclic peptides orally bioavailable can guide the design of new peptide drugs that are easier to administer and more effective. This knowledge is crucial for advancing peptide therapeutics beyond injections to convenient oral forms.
How the study worked
This study is a literature review analyzing past research on the oral bioavailability of peptides, focusing on passive permeability factors and comparing linear and cyclic peptide data.
What this study cannot tell us
As a review, it summarizes existing studies but does not provide new experimental data. The evidence strength and study types of included research vary and are not specified.
Read the original research
Cyclic peptide oral bioavailability: Lessons from the past.
Biopolymers, 106(6), 901-909
Citation
Wang, Conan K; Craik, David J. (2016). Cyclic peptide oral bioavailability: Lessons from the past.. Biopolymers, 106(6), 901-909. https://doi.org/10.1002/bip.22878