This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
MCoTI-II, a cyclic disulfide-rich peptide, predominantly distributes to serum and kidneys in mice, indicating renal clearance, and does not penetrate the brain despite being a cell-penetrating peptide.
Why it matters
Understanding the distribution and clearance of stable cyclic peptides like MCoTI-II is crucial for developing them as drug scaffolds, especially for targeting specific organs or avoiding others like the brain.
How the study worked
The study compared the biodistribution of MCoTI-II in mice to other peptides and proteins by measuring their presence in various organs, focusing on serum, kidneys, and brain tissues.
What this study cannot tell us
The study was conducted in mice, which may not fully represent human pharmacokinetics, and the exact doses and administration routes were not specified.
Read the original research
Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.
Journal of peptide science : an official publication of the European Peptide Society, 22(5), 305-10
Citation
Wang, Conan K; Stalmans, Sofie; De Spiegeleer, Bart; Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.. Journal of peptide science : an official publication of the European Peptide Society, 22(5), 305-10. https://doi.org/10.1002/psc.2862