Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.
Quick Facts
What This Study Found
MCoTI-II, a cyclic disulfide-rich peptide, predominantly distributes to serum and kidneys in mice, indicating renal clearance, and does not penetrate the brain despite being a cell-penetrating peptide.
Key Numbers
How They Did This
The study compared the biodistribution of MCoTI-II in mice to other peptides and proteins by measuring their presence in various organs, focusing on serum, kidneys, and brain tissues.
Why This Research Matters
Understanding the distribution and clearance of stable cyclic peptides like MCoTI-II is crucial for developing them as drug scaffolds, especially for targeting specific organs or avoiding others like the brain.
What This Study Doesn't Tell Us
The study was conducted in mice, which may not fully represent human pharmacokinetics, and the exact doses and administration routes were not specified.
Trust & Context
- Original Title:
- Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.
- Published In:
- Journal of peptide science : an official publication of the European Peptide Society, 22(5), 305-10 (2016)
- Authors:
- Wang, Conan K(2), Stalmans, Sofie, De Spiegeleer, Bart(3), Craik, David J
- Database ID:
- RPEP-03153
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-03153APA
Wang, Conan K; Stalmans, Sofie; De Spiegeleer, Bart; Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.. Journal of peptide science : an official publication of the European Peptide Society, 22(5), 305-10. https://doi.org/10.1002/psc.2862
MLA
Wang, Conan K, et al. "Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.." Journal of peptide science : an official publication of the European Peptide Society, 2016. https://doi.org/10.1002/psc.2862
RethinkPeptides
RethinkPeptides Research Database. "Biodistribution of the cyclotide MCoTI-II, a cyclic disulfid..." RPEP-03153. Retrieved from https://rethinkpeptides.com/research/wang-2016-biodistribution-of-the-cyclotide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.