Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
Quick Facts
What This Study Found
ACE2 efficiently cleaves pyr-apelin 13 and apelin 17 peptides, reducing their vasodilatory and cardioprotective effects. ACE2 knockout or inhibition enhances apelin peptide activity, while ACE2-generated cleavage products lack these beneficial functions. Stable apelin analogues resistant to ACE2 degradation retain biological activity.
Key Numbers
How They Did This
The study combined computer modeling, experiments in ACE2 knockout mice, pharmacological ACE2 inhibition, biochemical assays with recombinant ACE2, and functional tests on endothelial cells and myocardial ischemia-reperfusion models. Synthetic apelin analogues resistant to ACE2 cleavage were also designed and tested.
Why This Research Matters
Understanding how ACE2 degrades apelin peptides helps explain their short lifespan and guides the design of more stable apelin-based drugs for cardiovascular diseases.
What This Study Doesn't Tell Us
The study does not specify clinical trial data or long-term effects of stable apelin analogues in humans, and the exact therapeutic potential remains to be confirmed.
Trust & Context
- Original Title:
- Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
- Published In:
- Hypertension (Dallas, Tex. : 1979), 68(2), 365-77 (2016)
- Authors:
- Wang, Wang, McKinnie, Shaun M K, Farhan, Maikel, Paul, Manish, McDonald, Tyler, McLean, Brent, Llorens-Cortes, Catherine, Hazra, Saugata, Murray, Allan G, Vederas, John C, Oudit, Gavin Y
- Database ID:
- RPEP-03157
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-03157APA
Wang, Wang; McKinnie, Shaun M K; Farhan, Maikel; Paul, Manish; McDonald, Tyler; McLean, Brent; Llorens-Cortes, Catherine; Hazra, Saugata; Murray, Allan G; Vederas, John C; Oudit, Gavin Y. (2016). Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.. Hypertension (Dallas, Tex. : 1979), 68(2), 365-77. https://doi.org/10.1161/HYPERTENSIONAHA.115.06892
MLA
Wang, Wang, et al. "Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.." Hypertension (Dallas, 2016. https://doi.org/10.1161/HYPERTENSIONAHA.115.06892
RethinkPeptides
RethinkPeptides Research Database. "Angiotensin-Converting Enzyme 2 Metabolizes and Partially In..." RPEP-03157. Retrieved from https://rethinkpeptides.com/research/wang-2016-angiotensinconverting-enzyme-2-metabolizes
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.