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Study breakdown

NT-proCNP and CNP Don't Correlate in Heart Disease: Different Sources and Regulation

evidence
The takeaway

NT-proCNP and CNP levels did not correlate in cardiac patients, reflecting their different tissue sources and clearance — they measure different aspects of vascular biology and should not be used interchangeably.

Key finding

NT-proCNP and CNP levels did not correlate in cardiac patients, reflecting their different tissue sources and clearance — they measure different aspec

What the researchers found

NT-proCNP and CNP levels did not correlate in cardiac patients, reflecting their different tissue sources and clearance — they measure different aspects of vascular biology and should not be used interchangeably.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2010.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
NT-proCNP and CNP Don't Correlate in Heart Disease: Different Sources and Regulation
What was found?
NT-proCNP and CNP levels did not correlate in cardiac patients, reflecting their different tissue sources and clearance — they measure different aspects of vascular biology and should not be used interchangeably.

Read the original research

Amino-terminal fragment of C-type natriuretic peptide precursor and C-type natriuretic peptide do not correlate in patients with Chagas disease: role for neutral endopeptidase.

Journal of cardiovascular pharmacology, 55(1), 62-6

Citation

Wang, Yong; Moreira, Maria da Consolação V; Heringer-Walther, Silvia; Schultheiss, Heinz-Peter; Siems, Wolf-Eberhard; Wessel, Niels; Walther, Thomas. (2010). Amino-terminal fragment of C-type natriuretic peptide precursor and C-type natriuretic peptide do not correlate in patients with Chagas disease: role for neutral endopeptidase.. Journal of cardiovascular pharmacology, 55(1), 62-6. https://doi.org/10.1097/FJC.0b013e3181c37dc2