Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
Quick Facts
What This Study Found
Acute endurance exercise significantly elevated circulating humanin but not MOTS-c, while resistance exercise changed neither. Baseline MDP levels correlated with age but not fitness.
Key Numbers
30 subjects; 10 per group; 45 min cycling at 70% VO2max; 4x7RM leg exercises; humanin increased significantly after endurance; MOTS-c trended up; humanin correlated with age
How They Did This
Randomized controlled study. 30 subjects split into endurance (n=10, 45 min cycling at 70% VO2max), resistance (n=10, 4 sets x 7RM), or control (n=10). Blood and muscle biopsies at baseline, 30 min, and 3 hours post-exercise.
Why This Research Matters
MDPs are linked to aging and metabolic health. Finding that exercise stimulates them in humans could explain some of exercise's protective benefits.
What This Study Doesn't Tell Us
Small sample (10 per group). Single exercise bout. Did not test different exercise intensities or durations. MOTS-c trend did not reach significance.
Trust & Context
- Original Title:
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
- Published In:
- Journal of applied physiology (Bethesda, Md. : 1985), 131(3), 1035-1042 (2021)
- Authors:
- von Walden, Ferdinand, Fernandez-Gonzalo, Rodrigo, Norrbom, Jessica, Emanuelsson, Eric B, Figueiredo, Vandré C, Gidlund, Eva-Karin, Norrbrand, Lena, Liu, Chang, Sandström, Philip, Hansson, Björn, Wan, Junxiang, Cohen, Pinchas, Alkner, Björn
- Database ID:
- RPEP-05845
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05845APA
von Walden, Ferdinand; Fernandez-Gonzalo, Rodrigo; Norrbom, Jessica; Emanuelsson, Eric B; Figueiredo, Vandré C; Gidlund, Eva-Karin; Norrbrand, Lena; Liu, Chang; Sandström, Philip; Hansson, Björn; Wan, Junxiang; Cohen, Pinchas; Alkner, Björn. (2021). Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.. Journal of applied physiology (Bethesda, Md. : 1985), 131(3), 1035-1042. https://doi.org/10.1152/japplphysiol.00706.2019
MLA
von Walden, Ferdinand, et al. "Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.." Journal of applied physiology (Bethesda, 2021. https://doi.org/10.1152/japplphysiol.00706.2019
RethinkPeptides
RethinkPeptides Research Database. "Acute endurance exercise stimulates circulating levels of mi..." RPEP-05845. Retrieved from https://rethinkpeptides.com/research/von-2021-acute-endurance-exercise-stimulates
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.