This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Acute endurance exercise significantly elevated circulating humanin but not MOTS-c, while resistance exercise changed neither. Baseline MDP levels correlated with age but not fitness.
Why it matters
MDPs are linked to aging and metabolic health. Finding that exercise stimulates them in humans could explain some of exercise's protective benefits.
The numbers in context
30 subjects; 10 per group; 45 min cycling at 70% VO2max; 4x7RM leg exercises; humanin increased significantly after endurance; MOTS-c trended up; humanin correlated with age
How the study worked
Randomized controlled study. 30 subjects split into endurance (n=10, 45 min cycling at 70% VO2max), resistance (n=10, 4 sets x 7RM), or control (n=10). Blood and muscle biopsies at baseline, 30 min, and 3 hours post-exercise.
Who was studied
30 human subjects randomized to endurance exercise, resistance exercise, or control
What this study cannot tell us
Small sample (10 per group). Single exercise bout. Did not test different exercise intensities or durations. MOTS-c trend did not reach significance.
Read the original research
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
Journal of applied physiology (Bethesda, Md. : 1985), 131(3), 1035-1042
Citation
von Walden, Ferdinand; Fernandez-Gonzalo, Rodrigo; Norrbom, Jessica; Emanuelsson, Eric B; Figueiredo, Vandré C; Gidlund, Eva-Karin; Norrbrand, Lena; Liu, Chang; Sandström, Philip; Hansson, Björn; Wan, Junxiang; Cohen, Pinchas; Alkner, Björn. (2021). Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.. Journal of applied physiology (Bethesda, Md. : 1985), 131(3), 1035-1042. https://doi.org/10.1152/japplphysiol.00706.2019