TCR signaling strength and cytokine environment jointly regulated VPAC-1 receptor expression on CD4 T-cells, determining their sensitivity to VIP's immunomodulatory effects — context-dependent neuropeptide immune regulation.
Key findingCD4 T-cell VPAC-1 receptor expression was regulated by TCR activation strength and cytokine milieu (IL-2, IL-7, IL-15), determining VIP immunomodulato
What the researchers found
CD4 T-cell VPAC-1 receptor expression was regulated by TCR activation strength and cytokine milieu (IL-2, IL-7, IL-15), determining VIP immunomodulatory sensitivity — explaining context-dependent neuropeptide-immune regulation at the T-cell level.
Why it matters
Relevant for neuropeptides, immune-function.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells.
Brain, behavior, and immunity, 22(7), 1032-1040
Citation
Vomhof-DeKrey, Emilie E; Hermann, Rebecca J; Palmer, Megan F; Benton, Keith D; Sandy, Ashley R; Dorsam, Sheri T; Dorsam, Glenn Paul. (2008). TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells.. Brain, behavior, and immunity, 22(7), 1032-1040. https://doi.org/10.1016/j.bbi.2008.04.005