T-Cell Activation and Environment Control How Sensitive T-Cells Are to VIP Anti-Inflammatory Peptide
TCR signaling strength and cytokine environment jointly regulated VPAC-1 receptor expression on CD4 T-cells, determining their sensitivity to VIP's immunomodulatory effects — context-dependent neuropeptide immune regulation.
Quick Facts
What This Study Found
CD4 T-cell VPAC-1 receptor expression was regulated by TCR activation strength and cytokine milieu (IL-2, IL-7, IL-15), determining VIP immunomodulatory sensitivity — explaining context-dependent neuropeptide-immune regulation at the T-cell level.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for neuropeptides, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding CD4 T-cell VPAC-1 receptor expression was regulated by TCR activation strength and cytokine milieu (IL-2, IL-7, IL-15), determining VIP immunomodulato
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells.
- Published In:
- Brain, behavior, and immunity, 22(7), 1032-1040 (2008)
- Authors:
- Vomhof-DeKrey, Emilie E(2), Hermann, Rebecca J, Palmer, Megan F, Benton, Keith D, Sandy, Ashley R, Dorsam, Sheri T, Dorsam, Glenn Paul
- Database ID:
- RPEP-01435
Evidence Hierarchy
Frequently Asked Questions
What was studied?
T-Cell Activation and Environment Control How Sensitive T-Cells Are to VIP Anti-Inflammatory Peptide
What was found?
TCR signaling strength and cytokine environment jointly regulated VPAC-1 receptor expression on CD4 T-cells, determining their sensitivity to VIP's immunomodulatory effects — context-dependent neuropeptide immune regulation.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01435APA
Vomhof-DeKrey, Emilie E; Hermann, Rebecca J; Palmer, Megan F; Benton, Keith D; Sandy, Ashley R; Dorsam, Sheri T; Dorsam, Glenn Paul. (2008). TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells.. Brain, behavior, and immunity, 22(7), 1032-1040. https://doi.org/10.1016/j.bbi.2008.04.005
MLA
Vomhof-DeKrey, Emilie E, et al. "TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells.." Brain, 2008. https://doi.org/10.1016/j.bbi.2008.04.005
RethinkPeptides
RethinkPeptides Research Database. "TCR signaling and environment affect vasoactive intestinal p..." RPEP-01435. Retrieved from https://rethinkpeptides.com/research/vomhof-dekrey-2008-tcr-signaling-and-environment
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.