VIP Receptor Expression on Immune Cells Is Dynamically Regulated by Inflammatory Signals
VPAC-1 receptor expression on primary mouse macrophages was regulated by both stimulatory (LPS, IFN-γ) and suppressive (IL-10, TGF-β) signals, explaining how the VIP anti-inflammatory system adapts to inflammatory context.
Quick Facts
What This Study Found
VPAC-1 receptor on macrophages was upregulated by pro-inflammatory signals (LPS, IFN-γ) and downregulated by anti-inflammatory signals (IL-10, TGF-β) — dynamic receptor regulation that adapts VIP anti-inflammatory sensitivity to the inflammatory microenvironment.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for neuropeptides, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding VPAC-1 receptor on macrophages was upregulated by pro-inflammatory signals (LPS, IFN-γ) and downregulated by anti-inflammatory signals (IL-10, TGF-β)
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells.
- Published In:
- Brain, behavior, and immunity, 22(7), 1024-1031 (2008)
- Authors:
- Vomhof-DeKrey, Emilie E(2), Dorsam, Glenn Paul(2)
- Database ID:
- RPEP-01434
Evidence Hierarchy
Frequently Asked Questions
What was studied?
VIP Receptor Expression on Immune Cells Is Dynamically Regulated by Inflammatory Signals
What was found?
VPAC-1 receptor expression on primary mouse macrophages was regulated by both stimulatory (LPS, IFN-γ) and suppressive (IL-10, TGF-β) signals, explaining how the VIP anti-inflammatory system adapts to inflammatory context.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01434APA
Vomhof-DeKrey, Emilie E; Dorsam, Glenn Paul. (2008). Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells.. Brain, behavior, and immunity, 22(7), 1024-1031. https://doi.org/10.1016/j.bbi.2008.04.006
MLA
Vomhof-DeKrey, Emilie E, et al. "Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells.." Brain, 2008. https://doi.org/10.1016/j.bbi.2008.04.006
RethinkPeptides
RethinkPeptides Research Database. "Stimulatory and suppressive signal transduction regulates va..." RPEP-01434. Retrieved from https://rethinkpeptides.com/research/vomhof-dekrey-2008-stimulatory-and-suppressive-signal
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.