Testosterone supplementation in healthy older men increased basal GH and IGF-1 secretion but did NOT potentiate the GH response to GHRP-2/GHRH peptide stimulation — testosterone works through different GH pathways than secretagogues.
Key findingTestosterone supplementation increased GH and IGF-1 in healthy older men through enhanced basal secretion but did not potentiate GHRP-2 or GHRH stimul
What the researchers found
Testosterone supplementation increased GH and IGF-1 in healthy older men through enhanced basal secretion but did not potentiate GHRP-2 or GHRH stimulation responses — testosterone and GH secretagogues work through independent, non-synergistic GH-axis pathways.
Why it matters
Relevant for ghrp, hormone-optimization.
How the study worked
RCT study on ghrp, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.
European journal of endocrinology, 153(4), 577-86
Citation
Veldhuis, Johannes D; Keenan, Daniel M; Mielke, Kristi; Miles, John M; Bowers, Cyril Y. (2005). Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.. European journal of endocrinology, 153(4), 577-86.