Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.
Quick Facts
What This Study Found
Neuronal PAC1 receptor deletion caused retinal neuron loss at baseline and increased neuron death and optic nerve damage in EAE, proving cell-autonomous neuroprotection by PACAP.
Key Numbers
PAC1 deletion reduced RGN count at baseline; increased EAE neuron loss; increased optic nerve axonopathy; increased microglia/macrophage presence
How They Did This
Animal study. Used AAV2 to deliver Cre recombinase to retinal neurons of floxed PAC1 mice. Subjected to EAE (MS model). Measured retinal ganglion cell counts, dendrites, optic nerve pathology, and microglia presence.
Why This Research Matters
MS treatments control inflammation but do not stop neurons from dying. PACAP's direct neuron protection could fill this gap.
What This Study Doesn't Tell Us
Mouse model. EAE does not perfectly replicate human MS. Only retinal neurons were studied. Other neuron types may respond differently.
Trust & Context
- Original Title:
- Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.
- Published In:
- Neurobiology of disease, 160, 105524 (2021)
- Authors:
- Van, Christina, Condro, Michael C, Ko, Henly H, Hoang, Anh Q, Zhu, Ruoyan, Lov, Kenny, Ricaflanca, Patrick T, Diep, Anna L, Nguyen, Nhat N M, Lipshutz, Gerald S, MacKenzie-Graham, Allan, Waschek, James A
- Database ID:
- RPEP-05839
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05839APA
Van, Christina; Condro, Michael C; Ko, Henly H; Hoang, Anh Q; Zhu, Ruoyan; Lov, Kenny; Ricaflanca, Patrick T; Diep, Anna L; Nguyen, Nhat N M; Lipshutz, Gerald S; MacKenzie-Graham, Allan; Waschek, James A. (2021). Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.. Neurobiology of disease, 160, 105524. https://doi.org/10.1016/j.nbd.2021.105524
MLA
Van, Christina, et al. "Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.." Neurobiology of disease, 2021. https://doi.org/10.1016/j.nbd.2021.105524
RethinkPeptides
RethinkPeptides Research Database. "Targeted deletion of PAC1 receptors in retinal neurons enhan..." RPEP-05839. Retrieved from https://rethinkpeptides.com/research/van-2021-targeted-deletion-of-pac1
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.