This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
3-Hydroxyflavone reduced paclitaxel-induced neuropathic pain in rats by suppressing spinal cord CGRP, substance P, and inflammatory cytokines, with NK1R as the likely primary target.
Why it matters
Chemotherapy-induced nerve pain has no good treatments. A compound that targets multiple pain pathways could be more effective than current options.
The numbers in context
Paclitaxel 4 mg/kg days 1,3,5,7; reduced TNF-a, IL-1b, IL-6, CGRP, substance P mRNA; NK1R predicted strongest binding target
How the study worked
Animal study. Induced peripheral neuropathy with paclitaxel (4 mg/kg on days 1, 3, 5, 7) in rats. Treated with 3HF. Measured pain behaviors, spinal cord gene expression (RT-PCR), and computational docking.
Who was studied
Mice (pain tests) and Sprague Dawley rats (neuropathy model)
What this study cannot tell us
Animal study in rats. Computational docking is prediction, not proven binding. 3HF has not been tested in humans for this use. Specific dose not detailed.
Read the original research
Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.
Neurochemistry international, 144, 104981
Citation
Ullah, Rahim; Ali, Gowhar; Subhan, Fazal; Naveed, Muhammad; Khan, Ajmal; Khan, Jawad; Halim, Sobia Ahsan; Ahmad, Nisar; Zakiullah; Al-Harrasi, Ahmed. (2021). Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.. Neurochemistry international, 144, 104981. https://doi.org/10.1016/j.neuint.2021.104981