Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.
Quick Facts
What This Study Found
3-Hydroxyflavone reduced paclitaxel-induced neuropathic pain in rats by suppressing spinal cord CGRP, substance P, and inflammatory cytokines, with NK1R as the likely primary target.
Key Numbers
Paclitaxel 4 mg/kg days 1,3,5,7; reduced TNF-a, IL-1b, IL-6, CGRP, substance P mRNA; NK1R predicted strongest binding target
How They Did This
Animal study. Induced peripheral neuropathy with paclitaxel (4 mg/kg on days 1, 3, 5, 7) in rats. Treated with 3HF. Measured pain behaviors, spinal cord gene expression (RT-PCR), and computational docking.
Why This Research Matters
Chemotherapy-induced nerve pain has no good treatments. A compound that targets multiple pain pathways could be more effective than current options.
What This Study Doesn't Tell Us
Animal study in rats. Computational docking is prediction, not proven binding. 3HF has not been tested in humans for this use. Specific dose not detailed.
Trust & Context
- Original Title:
- Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.
- Published In:
- Neurochemistry international, 144, 104981 (2021)
- Authors:
- Ullah, Rahim, Ali, Gowhar, Subhan, Fazal, Naveed, Muhammad, Khan, Ajmal, Khan, Jawad, Halim, Sobia Ahsan, Ahmad, Nisar, Zakiullah, Al-Harrasi, Ahmed
- Database ID:
- RPEP-05834
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05834APA
Ullah, Rahim; Ali, Gowhar; Subhan, Fazal; Naveed, Muhammad; Khan, Ajmal; Khan, Jawad; Halim, Sobia Ahsan; Ahmad, Nisar; Zakiullah; Al-Harrasi, Ahmed. (2021). Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.. Neurochemistry international, 144, 104981. https://doi.org/10.1016/j.neuint.2021.104981
MLA
Ullah, Rahim, et al. "Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone.." Neurochemistry international, 2021. https://doi.org/10.1016/j.neuint.2021.104981
RethinkPeptides
RethinkPeptides Research Database. "Attenuation of nociceptive and paclitaxel-induced neuropathi..." RPEP-05834. Retrieved from https://rethinkpeptides.com/research/ullah-2021-attenuation-of-nociceptive-and
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.