Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide.
Quick Facts
What This Study Found
Pramlintide released from the silica depot maintained a steady serum concentration of 500 pM for 60 days.
Key Numbers
How They Did This
The study involved formulating a silica microparticle hydrogel depot and testing its drug release in a rat model.
Why This Research Matters
This method could improve diabetes treatment by reducing the need for frequent dosing and minimizing hypoglycemia risks. It represents a significant advancement in drug delivery technology.
What This Study Doesn't Tell Us
The study was conducted in rats, and results may not directly translate to humans. Further studies are needed to assess safety and efficacy in human subjects.
Trust & Context
- Original Title:
- Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide.
- Published In:
- Pharmaceutics, 14(3) (2022)
- Authors:
- Tyagi, Puneet, Koskinen, Mika, Mikkola, Jari, Sarkhel, Sanjay, Leino, Lasse, Seth, Asha, Madalli, Shimona, Will, Sarah, Howard, Victor G, Brant, Helen, Corkill, Dominic
- Database ID:
- RPEP-06553
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06553APA
Tyagi, Puneet; Koskinen, Mika; Mikkola, Jari; Sarkhel, Sanjay; Leino, Lasse; Seth, Asha; Madalli, Shimona; Will, Sarah; Howard, Victor G; Brant, Helen; Corkill, Dominic. (2022). Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide.. Pharmaceutics, 14(3). https://doi.org/10.3390/pharmaceutics14030553
MLA
Tyagi, Puneet, et al. "Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide.." Pharmaceutics, 2022. https://doi.org/10.3390/pharmaceutics14030553
RethinkPeptides
RethinkPeptides Research Database. "Injectable Biodegradable Silica Depot: Two Months of Sustain..." RPEP-06553. Retrieved from https://rethinkpeptides.com/research/tyagi-2022-injectable-biodegradable-silica-depot
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.