This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Multi-layered oral peptide particles with permeation enhancers showed improved bioavailability in dogs, with higher disintegration pH being most effective.
Why it matters
Most peptide drugs require injection. This layered approach could make oral peptide pills practical for conditions like diabetes.
The numbers in context
Disintegration pH 5.5 and 7.0; high-pH improved bioavailability; fluidized bed layering technique; sustained-release and mucoadhesive coatings
How the study worked
Formulation development study. Created layered particles using fluidized bed coating. Tested dissolution in vitro and pharmacokinetics in beagle dogs.
Who was studied
Beagle dogs (pharmacokinetic study)
What this study cannot tell us
Tested in dogs, not humans. Specific peptide and bioavailability numbers not detailed in abstract. Dog gut physiology differs from human.
Read the original research
Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.
Journal of controlled release : official journal of the Controlled Release Society, 338, 784-791
Citation
Tyagi, Puneet; Trivedi, Ruchit; Pechenov, Sergei; Patel, Chandresh; Revell, Jefferson; Wills, Sarah; Huang, Yue; Rosenbaum, Anton I; Subramony, J Anand. (2021). Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.. Journal of controlled release : official journal of the Controlled Release Society, 338, 784-791. https://doi.org/10.1016/j.jconrel.2021.09.002