Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.
Quick Facts
What This Study Found
Multi-layered oral peptide particles with permeation enhancers showed improved bioavailability in dogs, with higher disintegration pH being most effective.
Key Numbers
Disintegration pH 5.5 and 7.0; high-pH improved bioavailability; fluidized bed layering technique; sustained-release and mucoadhesive coatings
How They Did This
Formulation development study. Created layered particles using fluidized bed coating. Tested dissolution in vitro and pharmacokinetics in beagle dogs.
Why This Research Matters
Most peptide drugs require injection. This layered approach could make oral peptide pills practical for conditions like diabetes.
What This Study Doesn't Tell Us
Tested in dogs, not humans. Specific peptide and bioavailability numbers not detailed in abstract. Dog gut physiology differs from human.
Trust & Context
- Original Title:
- Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.
- Published In:
- Journal of controlled release : official journal of the Controlled Release Society, 338, 784-791 (2021)
- Authors:
- Tyagi, Puneet, Trivedi, Ruchit, Pechenov, Sergei, Patel, Chandresh, Revell, Jefferson, Wills, Sarah, Huang, Yue, Rosenbaum, Anton I, Subramony, J Anand
- Database ID:
- RPEP-05831
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05831APA
Tyagi, Puneet; Trivedi, Ruchit; Pechenov, Sergei; Patel, Chandresh; Revell, Jefferson; Wills, Sarah; Huang, Yue; Rosenbaum, Anton I; Subramony, J Anand. (2021). Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.. Journal of controlled release : official journal of the Controlled Release Society, 338, 784-791. https://doi.org/10.1016/j.jconrel.2021.09.002
MLA
Tyagi, Puneet, et al. "Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.." Journal of controlled release : official journal of the Controlled Release Society, 2021. https://doi.org/10.1016/j.jconrel.2021.09.002
RethinkPeptides
RethinkPeptides Research Database. "Targeted oral peptide delivery using multi-unit particulates..." RPEP-05831. Retrieved from https://rethinkpeptides.com/research/tyagi-2021-targeted-oral-peptide-delivery
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.