Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).
Quick Facts
What This Study Found
Exenatide showed weak interactions with sodium caprate and SNAC, with dissociation constants of approximately 10 µM and 30 µM, respectively.
Key Numbers
How They Did This
The study employed dynamic light scattering, surface plasmon resonance, isothermal titration calorimetry, and affinity capillary electrophoresis to analyze the interactions.
Why This Research Matters
Understanding these interactions is crucial for improving the oral bioavailability of peptide drugs like exenatide. This knowledge could lead to better formulations for effective oral delivery.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro interactions, which may not fully represent in vivo conditions in the human gastrointestinal tract.
Trust & Context
- Original Title:
- Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).
- Published In:
- International journal of pharmaceutics, 626, 122131 (2022)
- Authors:
- Twarog, Caroline, Fattal, Elias, Noiray, Magali, Illel, Brigitte, Brayden, David J, Taverna, Myriam, Hillaireau, Hervé
- Database ID:
- RPEP-06552
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06552APA
Twarog, Caroline; Fattal, Elias; Noiray, Magali; Illel, Brigitte; Brayden, David J; Taverna, Myriam; Hillaireau, Hervé. (2022). Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).. International journal of pharmaceutics, 626, 122131. https://doi.org/10.1016/j.ijpharm.2022.122131
MLA
Twarog, Caroline, et al. "Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).." International journal of pharmaceutics, 2022. https://doi.org/10.1016/j.ijpharm.2022.122131
RethinkPeptides
RethinkPeptides Research Database. "Characterization of the physicochemical interactions between..." RPEP-06552. Retrieved from https://rethinkpeptides.com/research/twarog-2022-characterization-of-the-physicochemical
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.