This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Exenatide showed weak interactions with sodium caprate and SNAC, with dissociation constants of approximately 10 µM and 30 µM, respectively.
Why it matters
Understanding these interactions is crucial for improving the oral bioavailability of peptide drugs like exenatide. This knowledge could lead to better formulations for effective oral delivery.
How the study worked
The study employed dynamic light scattering, surface plasmon resonance, isothermal titration calorimetry, and affinity capillary electrophoresis to analyze the interactions.
What this study cannot tell us
The study primarily focuses on in vitro interactions, which may not fully represent in vivo conditions in the human gastrointestinal tract.
Read the original research
Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).
International journal of pharmaceutics, 626, 122131
Citation
Twarog, Caroline; Fattal, Elias; Noiray, Magali; Illel, Brigitte; Brayden, David J; Taverna, Myriam; Hillaireau, Hervé. (2022). Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC).. International journal of pharmaceutics, 626, 122131. https://doi.org/10.1016/j.ijpharm.2022.122131