CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.
Quick Facts
What This Study Found
Compound 5 showed remarkable functional selectivity toward the hMC1R receptor.
Key Numbers
How They Did This
The study utilized a Chemical Linkage of Peptide onto Scaffolds strategy to modify melanotan II and assessed binding affinities through molecular dynamics simulations.
Why This Research Matters
Improving selectivity of receptor agonists can lead to better therapeutic options with fewer side effects. This research contributes to the development of targeted treatments for conditions influenced by melanocortin receptors.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro findings, which may not fully translate to in vivo results or human applications.
Trust & Context
- Original Title:
- CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.
- Published In:
- Journal of medicinal chemistry, 65(5), 4007-4017 (2022)
- Authors:
- Tomassi, Stefano, Dimmito, Marilisa Pia, Cai, Minying, D'Aniello, Antonia, Del Bene, Alessandra, Messere, Anna, Liu, Zekun, Zhu, Tingyi, Hruby, Victor J, Stefanucci, Azzurra, Cosconati, Sandro, Mollica, Adriano, Di Maro, Salvatore
- Database ID:
- RPEP-06543
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06543APA
Tomassi, Stefano; Dimmito, Marilisa Pia; Cai, Minying; D'Aniello, Antonia; Del Bene, Alessandra; Messere, Anna; Liu, Zekun; Zhu, Tingyi; Hruby, Victor J; Stefanucci, Azzurra; Cosconati, Sandro; Mollica, Adriano; Di Maro, Salvatore. (2022). CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.. Journal of medicinal chemistry, 65(5), 4007-4017. https://doi.org/10.1021/acs.jmedchem.1c01848
MLA
Tomassi, Stefano, et al. "CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.." Journal of medicinal chemistry, 2022. https://doi.org/10.1021/acs.jmedchem.1c01848
RethinkPeptides
RethinkPeptides Research Database. "CLIPSing Melanotan-II to Discover Multiple Functionally Sele..." RPEP-06543. Retrieved from https://rethinkpeptides.com/research/tomassi-2022-clipsing-melanotanii-to-discover
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.