Mitochondria-Targeted Peptide SS-31 Protects Pancreatic Islet Cells and Improves Diabetes
The mitochondria-targeted peptide SS-31 prevented pancreatic islet cell apoptosis, preserved insulin secretion, and improved diabetes outcomes in animal models — protecting the insulin-producing cells that diabetes destroys.
Quick Facts
What This Study Found
SS-31 (mitochondria-targeted peptide) prevented mitochondrial depolarization and apoptosis in pancreatic islet cells, preserved glucose-stimulated insulin secretion, and improved glycemic control in diabetic animals — protecting the beta-cells that diabetes progressively destroys.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for opioid-peptides, diabetes, neuroprotection.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding SS-31 (mitochondria-targeted peptide) prevented mitochondrial depolarization and apoptosis in pancreatic islet cells, preserved glucose-stimulated ins
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.
- Published In:
- Journal of the American Society of Nephrology : JASN, 18(1), 213-22 (2007)
- Authors:
- Thomas, Dolca A, Stauffer, Craig, Zhao, Kesheng(2), Yang, Hua, Sharma, Vijay K, Szeto, Hazel H, Suthanthiran, Manikkam
- Database ID:
- RPEP-01295
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Mitochondria-Targeted Peptide SS-31 Protects Pancreatic Islet Cells and Improves Diabetes
What was found?
The mitochondria-targeted peptide SS-31 prevented pancreatic islet cell apoptosis, preserved insulin secretion, and improved diabetes outcomes in animal models — protecting the insulin-producing cells that diabetes destroys.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01295APA
Thomas, Dolca A; Stauffer, Craig; Zhao, Kesheng; Yang, Hua; Sharma, Vijay K; Szeto, Hazel H; Suthanthiran, Manikkam. (2007). Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.. Journal of the American Society of Nephrology : JASN, 18(1), 213-22.
MLA
Thomas, Dolca A, et al. "Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.." Journal of the American Society of Nephrology : JASN, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Mitochondrial targeting with antioxidant peptide SS-31 preve..." RPEP-01295. Retrieved from https://rethinkpeptides.com/research/thomas-2007-mitochondrial-targeting-with-antioxidant
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.