The fatty acid metabolite 14,15-EET produced pain relief by triggering release of beta-endorphin and met-enkephalin, establishing a lipid-opioid peptide connection for pain modulation.
Key finding14,15-Epoxyeicosatrienoic acid (EET) produced antinociception mediated by beta-endorphin and met-enkephalin release (confirmed by antisera blocking),
What the researchers found
14,15-Epoxyeicosatrienoic acid (EET) produced antinociception mediated by beta-endorphin and met-enkephalin release (confirmed by antisera blocking), establishing a lipid mediator → endogenous opioid peptide → pain relief signaling cascade.
Why it matters
Relevant for opioid-peptides, pain, neuropeptides.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
The Journal of pharmacology and experimental therapeutics, 326(2), 614-22
Citation
Terashvili, Maia; Tseng, Leon F; Wu, Hsiang-En; Narayanan, Jayashree; Hart, Lucas M; Falck, John R; Pratt, Phillip F; Harder, David R. (2008). Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.. The Journal of pharmacology and experimental therapeutics, 326(2), 614-22. https://doi.org/10.1124/jpet.108.136739