An Arachidonic Acid Metabolite Kills Pain by Releasing Beta-Endorphin and Met-Enkephalin
The fatty acid metabolite 14,15-EET produced pain relief by triggering release of beta-endorphin and met-enkephalin, establishing a lipid-opioid peptide connection for pain modulation.
Quick Facts
What This Study Found
14,15-Epoxyeicosatrienoic acid (EET) produced antinociception mediated by beta-endorphin and met-enkephalin release (confirmed by antisera blocking), establishing a lipid mediator → endogenous opioid peptide → pain relief signaling cascade.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for opioid-peptides, pain, neuropeptides.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding 14,15-Epoxyeicosatrienoic acid (EET) produced antinociception mediated by beta-endorphin and met-enkephalin release (confirmed by antisera blocking),
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
- Published In:
- The Journal of pharmacology and experimental therapeutics, 326(2), 614-22 (2008)
- Authors:
- Terashvili, Maia(2), Tseng, Leon F(5), Wu, Hsiang-En(5), Narayanan, Jayashree, Hart, Lucas M, Falck, John R, Pratt, Phillip F, Harder, David R
- Database ID:
- RPEP-01429
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
An Arachidonic Acid Metabolite Kills Pain by Releasing Beta-Endorphin and Met-Enkephalin
What was found?
The fatty acid metabolite 14,15-EET produced pain relief by triggering release of beta-endorphin and met-enkephalin, establishing a lipid-opioid peptide connection for pain modulation.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01429APA
Terashvili, Maia; Tseng, Leon F; Wu, Hsiang-En; Narayanan, Jayashree; Hart, Lucas M; Falck, John R; Pratt, Phillip F; Harder, David R. (2008). Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.. The Journal of pharmacology and experimental therapeutics, 326(2), 614-22. https://doi.org/10.1124/jpet.108.136739
MLA
Terashvili, Maia, et al. "Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.." The Journal of pharmacology and experimental therapeutics, 2008. https://doi.org/10.1124/jpet.108.136739
RethinkPeptides
RethinkPeptides Research Database. "Antinociception produced by 14,15-epoxyeicosatrienoic acid i..." RPEP-01429. Retrieved from https://rethinkpeptides.com/research/terashvili-2008-antinociception-produced-by-1415epoxyeicosatrienoic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.