Adrenomedullin Maintains Blood Vessel Barrier Integrity: Why It Matters for Sepsis and Inflammation
Adrenomedullin maintains endothelial barrier function and prevents vascular leak, explaining why it protects against sepsis-induced vascular collapse and why AM-targeting therapy could reduce organ damage.
Quick Facts
What This Study Found
Adrenomedullin maintains endothelial barrier integrity through Rac1-mediated adherens junction stabilization, preventing vascular leak during inflammation — the molecular basis for AM's protective role in sepsis and for AM-targeting therapy (adrecizumab) development.
Key Numbers
How They Did This
review study.
Why This Research Matters
Relevant for neuropeptides, cardiovascular, inflammation.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Adrenomedullin maintains endothelial barrier integrity through Rac1-mediated adherens junction stabilization, preventing vascular leak during inflamma
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Adrenomedullin and endothelial barrier function.
- Published In:
- Thrombosis and haemostasis, 98(5), 944-51 (2007)
- Database ID:
- RPEP-01294
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Adrenomedullin Maintains Blood Vessel Barrier Integrity: Why It Matters for Sepsis and Inflammation
What was found?
Adrenomedullin maintains endothelial barrier function and prevents vascular leak, explaining why it protects against sepsis-induced vascular collapse and why AM-targeting therapy could reduce organ damage.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01294APA
Temmesfeld-Wollbrück, Bettina; Hocke, Andreas C; Suttorp, Norbert; Hippenstiel, Stefan. (2007). Adrenomedullin and endothelial barrier function.. Thrombosis and haemostasis, 98(5), 944-51.
MLA
Temmesfeld-Wollbrück, Bettina, et al. "Adrenomedullin and endothelial barrier function.." Thrombosis and haemostasis, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Adrenomedullin and endothelial barrier function." RPEP-01294. Retrieved from https://rethinkpeptides.com/research/temmesfeld-wollbruck-2007-adrenomedullin-and-endothelial-barrier
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.