Adrenomedullin maintains endothelial barrier function and prevents vascular leak, explaining why it protects against sepsis-induced vascular collapse and why AM-targeting therapy could reduce organ damage.
Key findingAdrenomedullin maintains endothelial barrier integrity through Rac1-mediated adherens junction stabilization, preventing vascular leak during inflamma
What the researchers found
Adrenomedullin maintains endothelial barrier integrity through Rac1-mediated adherens junction stabilization, preventing vascular leak during inflammation — the molecular basis for AM's protective role in sepsis and for AM-targeting therapy (adrecizumab) development.
Why it matters
Relevant for neuropeptides, cardiovascular, inflammation.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Adrenomedullin and endothelial barrier function.
Thrombosis and haemostasis, 98(5), 944-51
Citation
Temmesfeld-Wollbrück, Bettina; Hocke, Andreas C; Suttorp, Norbert; Hippenstiel, Stefan. (2007). Adrenomedullin and endothelial barrier function.. Thrombosis and haemostasis, 98(5), 944-51.