PACAP Neuropeptide Protects Against Autoimmune Brain Inflammation by Generating Regulatory T-Cells
PACAP (pituitary adenylyl cyclase-activating polypeptide) intrinsically regulated Treg abundance and protected against experimental autoimmune encephalomyelitis (MS model), establishing it as a natural anti-autoimmune neuropeptide.
Quick Facts
What This Study Found
PACAP (pituitary adenylyl cyclase-activating polypeptide) intrinsically regulated Treg abundance and protected against experimental autoimmune encephalomyelitis (MS model), establishing it as a natural anti-autoimmune neuropeptide.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding PACAP (pituitary adenylyl cyclase-activating polypeptide) intrinsically regulated Treg abundance and protected against experimental autoimmune encepha
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2009.
- Original Title:
- Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 106(6), 2012-7 (2009)
- Authors:
- Tan, Yossan-Var(4), Abad, Catalina(4), Lopez, Robert(3), Dong, Hongmei, Liu, Shen, Lee, Alice, Gomariz, Rosa P, Leceta, Javier, Waschek, James A
- Database ID:
- RPEP-01552
Evidence Hierarchy
Frequently Asked Questions
What was studied?
PACAP Neuropeptide Protects Against Autoimmune Brain Inflammation by Generating Regulatory T-Cells
What was found?
PACAP (pituitary adenylyl cyclase-activating polypeptide) intrinsically regulated Treg abundance and protected against experimental autoimmune encephalomyelitis (MS model), establishing it as a natural anti-autoimmune neuropeptide.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01552APA
Tan, Yossan-Var; Abad, Catalina; Lopez, Robert; Dong, Hongmei; Liu, Shen; Lee, Alice; Gomariz, Rosa P; Leceta, Javier; Waschek, James A. (2009). Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis.. Proceedings of the National Academy of Sciences of the United States of America, 106(6), 2012-7. https://doi.org/10.1073/pnas.0812257106
MLA
Tan, Yossan-Var, et al. "Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis.." Proceedings of the National Academy of Sciences of the United States of America, 2009. https://doi.org/10.1073/pnas.0812257106
RethinkPeptides
RethinkPeptides Research Database. "Pituitary adenylyl cyclase-activating polypeptide is an intr..." RPEP-01552. Retrieved from https://rethinkpeptides.com/research/tan-2009-pituitary-adenylyl-cyclaseactivating-polypeptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.