Prolactin-Releasing Peptide Naturally Reduces Food Intake in Rodents
Endogenous prolactin-releasing peptide (PrRP) regulated food intake in rodents, with PrRP-deficient mice showing increased body weight and food intake — establishing PrRP as a natural satiety signal beyond its prolactin-releasing function.
Quick Facts
What This Study Found
PrRP-deficient mice showed increased food intake and body weight, while PrRP administration reduced feeding, establishing endogenous prolactin-releasing peptide as a novel satiety signal acting through hypothalamic and brainstem appetite circuits.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding PrRP-deficient mice showed increased food intake and body weight, while PrRP administration reduced feeding, establishing endogenous prolactin-releasi
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Endogenous prolactin-releasing peptide regulates food intake in rodents.
- Published In:
- The Journal of clinical investigation, 118(12), 4014-24 (2008)
- Authors:
- Takayanagi, Yuki(2), Matsumoto, Hirokazu, Nakata, Masanori, Mera, Takashi, Fukusumi, Shoji, Hinuma, Shuji, Ueta, Yoichi, Yada, Toshihiko, Leng, Gareth, Onaka, Tatsushi
- Database ID:
- RPEP-01427
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Prolactin-Releasing Peptide Naturally Reduces Food Intake in Rodents
What was found?
Endogenous prolactin-releasing peptide (PrRP) regulated food intake in rodents, with PrRP-deficient mice showing increased body weight and food intake — establishing PrRP as a natural satiety signal beyond its prolactin-releasing function.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01427APA
Takayanagi, Yuki; Matsumoto, Hirokazu; Nakata, Masanori; Mera, Takashi; Fukusumi, Shoji; Hinuma, Shuji; Ueta, Yoichi; Yada, Toshihiko; Leng, Gareth; Onaka, Tatsushi. (2008). Endogenous prolactin-releasing peptide regulates food intake in rodents.. The Journal of clinical investigation, 118(12), 4014-24. https://doi.org/10.1172/JCI34682
MLA
Takayanagi, Yuki, et al. "Endogenous prolactin-releasing peptide regulates food intake in rodents.." The Journal of clinical investigation, 2008. https://doi.org/10.1172/JCI34682
RethinkPeptides
RethinkPeptides Research Database. "Endogenous prolactin-releasing peptide regulates food intake..." RPEP-01427. Retrieved from https://rethinkpeptides.com/research/takayanagi-2008-endogenous-prolactinreleasing-peptide-regulates
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.