Endogenous prolactin-releasing peptide (PrRP) regulated food intake in rodents, with PrRP-deficient mice showing increased body weight and food intake — establishing PrRP as a natural satiety signal beyond its prolactin-releasing function.
Key findingPrRP-deficient mice showed increased food intake and body weight, while PrRP administration reduced feeding, establishing endogenous prolactin-releasi
What the researchers found
PrRP-deficient mice showed increased food intake and body weight, while PrRP administration reduced feeding, establishing endogenous prolactin-releasing peptide as a novel satiety signal acting through hypothalamic and brainstem appetite circuits.
Why it matters
Relevant for neuropeptides, weight-loss.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Endogenous prolactin-releasing peptide regulates food intake in rodents.
The Journal of clinical investigation, 118(12), 4014-24
Citation
Takayanagi, Yuki; Matsumoto, Hirokazu; Nakata, Masanori; Mera, Takashi; Fukusumi, Shoji; Hinuma, Shuji; Ueta, Yoichi; Yada, Toshihiko; Leng, Gareth; Onaka, Tatsushi. (2008). Endogenous prolactin-releasing peptide regulates food intake in rodents.. The Journal of clinical investigation, 118(12), 4014-24. https://doi.org/10.1172/JCI34682