Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.
Quick Facts
What This Study Found
1α,25-dihydroxyvitamin D3 (1,25D3) significantly upregulates the CAMP gene and LL-37 protein expression in human keratinocytes, and this effect requires retinoid X receptor alpha (RXRα) but is independent of vitamin D receptor (VDR) upregulation.
Key Numbers
How They Did This
The study analyzed gene and protein expression in human skin and gingival biopsies and in cultured human keratinocyte (HaCaT) cells treated with 1,25D3. RXRα involvement was tested using short interfering RNA to knock down RXRα expression.
Why This Research Matters
Understanding how vitamin D regulates antimicrobial peptides via RXRα can inform new strategies to boost skin immunity and develop treatments for infections or skin disorders.
What This Study Doesn't Tell Us
The study was conducted primarily in cell cultures and tissue biopsies, which may not fully replicate in vivo skin conditions; the exact signaling pathways downstream of RXRα were not fully elucidated.
Trust & Context
- Original Title:
- Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.
- Published In:
- Cell and tissue research, 366(2), 353-362 (2016)
- Database ID:
- RPEP-03125
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-03125APA
Svensson, Daniel; Nebel, Daniel; Voss, Ulrikke; Ekblad, Eva; Nilsson, Bengt-Olof. (2016). Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.. Cell and tissue research, 366(2), 353-362. https://doi.org/10.1007/s00441-016-2449-z
MLA
Svensson, Daniel, et al. "Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.." Cell and tissue research, 2016. https://doi.org/10.1007/s00441-016-2449-z
RethinkPeptides
RethinkPeptides Research Database. "Vitamin D-induced up-regulation of human keratinocyte cathel..." RPEP-03125. Retrieved from https://rethinkpeptides.com/research/svensson-2016-vitamin-dinduced-upregulation-of
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.