Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.
Quick Facts
What This Study Found
Chronic social defeat stress reduced Paneth cell alpha-defensin secretion, causing dysbiosis and metabolite changes that were reversed by alpha-defensin administration in mice.
Key Numbers
CSDS reduced α-defensin secretion; induced dysbiosis; changed metabolites; all reversed by α-defensin administration; Paneth cells identified as stress-responsive
How They Did This
Mouse depression model (chronic social defeat stress). Measured Paneth cell alpha-defensin secretion. Analyzed intestinal microbiota composition and metabolites. Tested whether exogenous alpha-defensin administration could reverse stress-induced changes.
Why This Research Matters
The gut-brain connection in depression is increasingly recognized but poorly understood. This study identifies alpha-defensin as a key link between psychological stress, microbiome disruption, and potentially depression.
What This Study Doesn't Tell Us
Mouse model of depression, which has limitations in modeling human depression. Only one stress model tested. The specific microbiome and metabolite changes were not detailed in the abstract. Whether similar mechanisms operate in humans is unknown.
Trust & Context
- Original Title:
- Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.
- Published In:
- Scientific reports, 11(1), 9915 (2021)
- Authors:
- Suzuki, Kosuke, Nakamura, Kiminori(6), Shimizu, Yu(2), Yokoi, Yuki, Ohira, Shuya, Hagiwara, Mizu, Wang, Yi, Song, Yuchi, Aizawa, Tomoyasu, Ayabe, Tokiyoshi
- Database ID:
- RPEP-05801
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05801APA
Suzuki, Kosuke; Nakamura, Kiminori; Shimizu, Yu; Yokoi, Yuki; Ohira, Shuya; Hagiwara, Mizu; Wang, Yi; Song, Yuchi; Aizawa, Tomoyasu; Ayabe, Tokiyoshi. (2021). Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.. Scientific reports, 11(1), 9915. https://doi.org/10.1038/s41598-021-89308-y
MLA
Suzuki, Kosuke, et al. "Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.." Scientific reports, 2021. https://doi.org/10.1038/s41598-021-89308-y
RethinkPeptides
RethinkPeptides Research Database. "Decrease of α-defensin impairs intestinal metabolite homeost..." RPEP-05801. Retrieved from https://rethinkpeptides.com/research/suzuki-2021-decrease-of-defensin-impairs
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.