The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response.
Quick Facts
What This Study Found
CRH coordinates stress responses through CRHR1/CRHR2 in hypothalamic and extrahypothalamic brain regions, with dysregulation linked to depression, anxiety, addiction, and neurodegeneration, making CRHR1 a therapeutic target.
Key Numbers
2 receptors (CRHR1, CRHR2); HPA axis + extrahypothalamic pathways; linked to depression, anxiety, addiction, Alzheimer's; CRHR1 antagonists as potential antidepressants; CRH regulates brain structure
How They Did This
Narrative review of CRH system biology, receptor pharmacology, stress pathway mechanisms, and involvement in psychiatric and neurodegenerative disorders.
Why This Research Matters
Stress-related mental health disorders affect billions of people. Understanding the CRH system provides targets for new treatments that address the root biology of these conditions rather than just symptoms.
What This Study Doesn't Tell Us
Review based on animal and human studies of varying quality. CRHR1 antagonists have not yet proven effective in clinical trials. The complexity of the CRH system makes targeted intervention challenging.
Trust & Context
- Original Title:
- The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response.
- Published In:
- Vavilovskii zhurnal genetiki i selektsii, 25(2), 216-223 (2021)
- Authors:
- Sukhareva, E V
- Database ID:
- RPEP-05795
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05795APA
Sukhareva, E V. (2021). The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response.. Vavilovskii zhurnal genetiki i selektsii, 25(2), 216-223. https://doi.org/10.18699/VJ21.025
MLA
Sukhareva, E V. "The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response.." Vavilovskii zhurnal genetiki i selektsii, 2021. https://doi.org/10.18699/VJ21.025
RethinkPeptides
RethinkPeptides Research Database. "The role of the corticotropin-releasing hormone and its rece..." RPEP-05795. Retrieved from https://rethinkpeptides.com/research/sukhareva-2021-the-role-of-the
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.