This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
The nanofiber dressings significantly increased hCAP18/LL-37 expression in wounds compared to free drugs.
Why it matters
Surgical site infections are a major concern in healthcare, and enhancing the body's natural defenses could lead to better patient outcomes. This innovative dressing could provide a new strategy for infection prevention.
How the study worked
The study involved creating nanofiber dressings that coencapsulated 1α,25-dihydroxyvitamin D3 and VID400, followed by testing their effects on gene expression in vitro and in vivo.
What this study cannot tell us
The study primarily involved animal models, and further research is needed to confirm effectiveness in humans.
Read the original research
Codelivery of 1α,25-Dihydroxyvitamin D3 and CYP24A1 Inhibitor VID400 by Nanofiber Dressings Promotes Endogenous Antimicrobial Peptide LL-37 Induction.
Molecular pharmaceutics, 19(3), 974-984
Citation
Su, Yajuan; Ganguli-Indra, Gitali; Bhattacharya, Nilika; Logan, Isabelle E; Indra, Arup K; Gombart, Adrian F; Wong, Shannon L; Xie, Jingwei. (2022). Codelivery of 1α,25-Dihydroxyvitamin D3 and CYP24A1 Inhibitor VID400 by Nanofiber Dressings Promotes Endogenous Antimicrobial Peptide LL-37 Induction.. Molecular pharmaceutics, 19(3), 974-984. https://doi.org/10.1021/acs.molpharmaceut.1c00944