MR-proADM: A Stable Adrenomedullin Fragment Identified as a Sepsis Biomarker
A mid-regional pro-adrenomedullin fragment (MR-proADM) was identified in sepsis patient plasma as a stable, measurable surrogate for adrenomedullin — laying the groundwork for what became a major clinical sepsis biomarker.
Quick Facts
What This Study Found
A mid-regional pro-adrenomedullin (MR-proADM) fragment was identified and quantified in sepsis patient plasma, providing a stable, measurable surrogate for the unstable mature adrenomedullin — establishing the basis for clinical MR-proADM sepsis testing.
Key Numbers
How They Did This
clinical-trial study on neuropeptides, cardiovascular.
Why This Research Matters
Relevant for neuropeptides, cardiovascular, clinical-trials.
The Bigger Picture
Advances peptide therapeutics/biomarker research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding A mid-regional pro-adrenomedullin (MR-proADM) fragment was identified and quantified in sepsis patient plasma, providing a stable, measurable surrogat
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients.
- Published In:
- Peptides, 25(8), 1369-72 (2004)
- Authors:
- Struck, Joachim, Tao, Chen, Morgenthaler, Nils G(2), Bergmann, Andreas
- Database ID:
- RPEP-00981
Evidence Hierarchy
Frequently Asked Questions
What was studied?
MR-proADM: A Stable Adrenomedullin Fragment Identified as a Sepsis Biomarker
What was found?
A mid-regional pro-adrenomedullin fragment (MR-proADM) was identified in sepsis patient plasma as a stable, measurable surrogate for adrenomedullin — laying the groundwork for what became a major clinical sepsis biomarker.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00981APA
Struck, Joachim; Tao, Chen; Morgenthaler, Nils G; Bergmann, Andreas. (2004). Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients.. Peptides, 25(8), 1369-72.
MLA
Struck, Joachim, et al. "Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients.." Peptides, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Identification of an Adrenomedullin precursor fragment in pl..." RPEP-00981. Retrieved from https://rethinkpeptides.com/research/struck-2004-identification-of-an-adrenomedullin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.