Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.
Quick Facts
What This Study Found
Approximately 80% of desmopressin was released within 45 minutes, and 90% was retained on the mucosa after 15 minutes.
Key Numbers
How They Did This
The study developed a two-layered hybrid system combining peptide-loaded nanofibers and a saliva-repelling film, tested in vitro and ex vivo.
Why This Research Matters
This research provides a promising approach for delivering unstable therapeutic peptides, potentially improving their effectiveness and patient compliance.
What This Study Doesn't Tell Us
The study was conducted in vitro and ex vivo, which may not fully replicate human conditions.
Trust & Context
- Original Title:
- Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.
- Published In:
- International journal of molecular sciences, 23(3) (2022)
- Authors:
- Stie, Mai Bay, Gätke, Johan Ring, Chronakis, Ioannis S, Jacobsen, Jette, Nielsen, Hanne Mørck
- Database ID:
- RPEP-06516
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06516APA
Stie, Mai Bay; Gätke, Johan Ring; Chronakis, Ioannis S; Jacobsen, Jette; Nielsen, Hanne Mørck. (2022). Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.. International journal of molecular sciences, 23(3). https://doi.org/10.3390/ijms23031458
MLA
Stie, Mai Bay, et al. "Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.." International journal of molecular sciences, 2022. https://doi.org/10.3390/ijms23031458
RethinkPeptides
RethinkPeptides Research Database. "Mucoadhesive Electrospun Nanofiber-Based Hybrid System with ..." RPEP-06516. Retrieved from https://rethinkpeptides.com/research/stie-2022-mucoadhesive-electrospun-nanofiberbased-hybrid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.