This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Approximately 80% of desmopressin was released within 45 minutes, and 90% was retained on the mucosa after 15 minutes.
Why it matters
This research provides a promising approach for delivering unstable therapeutic peptides, potentially improving their effectiveness and patient compliance.
How the study worked
The study developed a two-layered hybrid system combining peptide-loaded nanofibers and a saliva-repelling film, tested in vitro and ex vivo.
What this study cannot tell us
The study was conducted in vitro and ex vivo, which may not fully replicate human conditions.
Read the original research
Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.
International journal of molecular sciences, 23(3)
Citation
Stie, Mai Bay; Gätke, Johan Ring; Chronakis, Ioannis S; Jacobsen, Jette; Nielsen, Hanne Mørck. (2022). Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin.. International journal of molecular sciences, 23(3). https://doi.org/10.3390/ijms23031458