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Study breakdown

Neuropeptide Autoimmunity May Contribute to Neuropsychiatric Disorders at the Blood-Brain Barrier

evidence
The takeaway

Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at the blood-brain/spinal barrier is postulated to contribute to multiple neuropsychiatric conditions including demyelinating and neurodegenerative diseases.

Key finding

Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at the blood-brain/spinal barrier is postulated to contribute to multiple neuropsychiatr

What the researchers found

Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at the blood-brain/spinal barrier is postulated to contribute to multiple neuropsychiatric conditions including demyelinating and neurodegenerative diseases.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2009.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Neuropeptide Autoimmunity May Contribute to Neuropsychiatric Disorders at the Blood-Brain Barrier
What was found?
Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at the blood-brain/spinal barrier is postulated to contribute to multiple neuropsychiatric conditions including demyelinating and neurodegenerative diseases.

Read the original research

Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Neuropsychiatric disease and treatment, 5, 81-9

Citation

Staines, Donald R; Brenu, Ekua W; Marshall-Gradisnik, Sonya. (2009). Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?. Neuropsychiatric disease and treatment, 5, 81-9.