Autoimmunity against vasoactive neuropeptides (VIP, PACAP) at the blood-brain barrier may contribute to neurodegenerative disease through impaired cerebral blood flow regulation and neuroinflammation.
Key findingAutoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at blood-brain barrier Virchow-Robin spaces may impair cerebral blood flow autoregulatio
What the researchers found
Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at blood-brain barrier Virchow-Robin spaces may impair cerebral blood flow autoregulation and promote neuroinflammation — a novel immunopathological theory for neurodegenerative diseases.
Why it matters
Relevant for neuropeptides, neuroprotection, inflammation.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Postulated role of vasoactive neuropeptide-related immunopathology of the blood brain barrier and Virchow-Robin spaces in the aetiology of neurological-related conditions.
Mediators of inflammation, 2008, 792428
Citation
Staines, D R; Brenu, E W; Marshall-Gradisnik, S. (2008). Postulated role of vasoactive neuropeptide-related immunopathology of the blood brain barrier and Virchow-Robin spaces in the aetiology of neurological-related conditions.. Mediators of inflammation, 2008, 792428. https://doi.org/10.1155/2008/792428