Neuropeptide Autoimmunity at the Blood-Brain Barrier: A New Theory for Neurodegenerative Disease
Autoimmunity against vasoactive neuropeptides (VIP, PACAP) at the blood-brain barrier may contribute to neurodegenerative disease through impaired cerebral blood flow regulation and neuroinflammation.
Quick Facts
What This Study Found
Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at blood-brain barrier Virchow-Robin spaces may impair cerebral blood flow autoregulation and promote neuroinflammation — a novel immunopathological theory for neurodegenerative diseases.
Key Numbers
How They Did This
review study.
Why This Research Matters
Relevant for neuropeptides, neuroprotection, inflammation.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) at blood-brain barrier Virchow-Robin spaces may impair cerebral blood flow autoregulatio
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Postulated role of vasoactive neuropeptide-related immunopathology of the blood brain barrier and Virchow-Robin spaces in the aetiology of neurological-related conditions.
- Published In:
- Mediators of inflammation, 2008, 792428 (2008)
- Authors:
- Staines, D R, Brenu, E W, Marshall-Gradisnik, S
- Database ID:
- RPEP-01422
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Neuropeptide Autoimmunity at the Blood-Brain Barrier: A New Theory for Neurodegenerative Disease
What was found?
Autoimmunity against vasoactive neuropeptides (VIP, PACAP) at the blood-brain barrier may contribute to neurodegenerative disease through impaired cerebral blood flow regulation and neuroinflammation.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01422APA
Staines, D R; Brenu, E W; Marshall-Gradisnik, S. (2008). Postulated role of vasoactive neuropeptide-related immunopathology of the blood brain barrier and Virchow-Robin spaces in the aetiology of neurological-related conditions.. Mediators of inflammation, 2008, 792428. https://doi.org/10.1155/2008/792428
MLA
Staines, D R, et al. "Postulated role of vasoactive neuropeptide-related immunopathology of the blood brain barrier and Virchow-Robin spaces in the aetiology of neurological-related conditions.." Mediators of inflammation, 2008. https://doi.org/10.1155/2008/792428
RethinkPeptides
RethinkPeptides Research Database. "Postulated role of vasoactive neuropeptide-related immunopat..." RPEP-01422. Retrieved from https://rethinkpeptides.com/research/staines-2008-postulated-role-of-vasoactive
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.